3-nitrotyrosine (3NT) level in biological samples, considered as an appropriate biomarker for nitrosative stress, is associated with many inflammatory and chronic diseases. In this research, a novel highly fluorescent hybrid material ([email protected]) has been synthesized by encapsulating gold nanoclusters (AuNCs) into the zeolitic imidazolate framework (ZIF-8). Due to the confinement-assisted emission enhancement, the quantum yield of [email protected] attained to 36.6 %, which was nearly 15 times that of the sole AuNCs. The obtained [email protected] composites were used to develop an ultrasensitive and highly selective sensor for 3NT. In comparison with sensing by pure AuNCs without the amplifying effect of ZIF-8, the developed [email protected] based sensor indicated almost two orders of magnitude lower limit of detection (LOD), and 3NT could be detected in the range of 5−200 nM with a detection limit of 1.8 nM (S/N = 3). The developed sensor was applied to quantify 3NT in biological samples and satisfactory results were obtained.

生物样品中的3-硝基酪氨酸（3NT）水平被认为是亚硝化应激的适当生物标志物，与许多炎症和慢性疾病有关。在这项研究中，通过将金纳米团簇（AuNCs）封装在沸石咪唑酸盐骨架（ZIF-8）中，合成了一种新型的高荧光杂化材料（[受电子邮件保护]）。由于限制辅助发射的增强，[受电子邮件保护]的量子产率达到了36.6％，几乎是唯一AuNCs的15倍。获得的[受电子邮件保护的]复合材料用于开发3NT的超灵敏和高选择性传感器。与没有ZIF-8放大作用的纯AuNC进行感应相比，已开发的[受电子邮件保护]的传感器显示出检测下限（LOD）几乎高出两个数量级，可以在5-200 nM的范围内检测到3NT，检测限为1.8 nM（S / N = 3）。研制的传感器用于定量生物样品中的3NT，获得了满意的结果。