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Incorporating of gold nanoclusters into metal-organic frameworks for highly sensitive detection of 3-nitrotyrosine as an oxidative stress biomarker
Journal of Photochemistry and Photobiology A: Chemistry ( IF 4.1 ) Pub Date : 2020-01-10 , DOI: 10.1016/j.jphotochem.2020.112370
Roghayeh Jalili , Mahsa Dastborhan , Salimeh Chenaghlou , Alireza Khataee

3-nitrotyrosine (3NT) level in biological samples, considered as an appropriate biomarker for nitrosative stress, is associated with many inflammatory and chronic diseases. In this research, a novel highly fluorescent hybrid material ([email protected]) has been synthesized by encapsulating gold nanoclusters (AuNCs) into the zeolitic imidazolate framework (ZIF-8). Due to the confinement-assisted emission enhancement, the quantum yield of [email protected] attained to 36.6 %, which was nearly 15 times that of the sole AuNCs. The obtained [email protected] composites were used to develop an ultrasensitive and highly selective sensor for 3NT. In comparison with sensing by pure AuNCs without the amplifying effect of ZIF-8, the developed [email protected] based sensor indicated almost two orders of magnitude lower limit of detection (LOD), and 3NT could be detected in the range of 5−200 nM with a detection limit of 1.8 nM (S/N = 3). The developed sensor was applied to quantify 3NT in biological samples and satisfactory results were obtained.



中文翻译:

将金纳米团簇结合到金属有机框架中,以高灵敏度检测3-硝基酪氨酸作为氧化应激生物标记

生物样品中的3-硝基酪氨酸(3NT)水平被认为是亚硝化应激的适当生物标志物,与许多炎症和慢性疾病有关。在这项研究中,通过将金纳米团簇(AuNCs)封装在沸石咪唑酸盐骨架(ZIF-8)中,合成了一种新型的高荧光杂化材料([受电子邮件保护])。由于限制辅助发射的增强,[受电子邮件保护]的量子产率达到了36.6%,几乎是唯一AuNCs的15倍。获得的[受电子邮件保护的]复合材料用于开发3NT的超灵敏和高选择性传感器。与没有ZIF-8放大作用的纯AuNC进行感应相比,已开发的[受电子邮件保护]的传感器显示出检测下限(LOD)几乎高出两个数量级,可以在5-200 nM的范围内检测到3NT,检测限为1.8 nM(S / N = 3)。研制的传感器用于定量生物样品中的3NT,获得了满意的结果。

更新日期:2020-01-10
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