The discovery of autoantibodies to ribosomal proteins (anti-RibP) dates back more than fifty years when antibodies to ribosomes were identified in systemic lupus erythematosus (SLE) sera. Over the years, anti-RibP autoantibodies have been the subject of extensive study and became known as a highly specific biomarker for the diagnosis of SLE and were associated with neuropsychiatric SLE (NPSLE), lupus nephritis (LN) and hepatitis (LH). As demonstrated by studies on cultured human cells and of murine models, there is evidence to suggest that anti-RibP may have a pathogenic role in LN and NPSLE. Despite a wealth of evidence, in comparison to other SLE autoantibodies such as anti-Sm and anti-dsDNA, anti-RibP has not been included in classification criteria for SLE. A significant challenge is the variability of assays used to detect anti-RibP, including the antigens and diagnostic platforms employed. This may account for the marked variation in frequencies (10-47%) in SLE and its association with clinical and demographic features reported in SLE cohorts. We performed a systematic literature review and meta-analysis to help clarify its prevalence, various clinical and serological associations in SLE based on the different RibP antigens and assay platforms used.

中文翻译：

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系统性红斑狼疮抗核糖体P自身抗体的综述和荟萃分析。

对核糖体蛋白（anti-RibP）的自身抗体的发现可以追溯到五十多年前，当时在系统性红斑狼疮（SLE）血清中鉴定了针对核糖体的抗体。多年来，抗RibP自身抗体已成为广泛研究的主题，并已成为诊断SLE的高度特异性生物标志物，并与神经精神病性SLE（NPSLE），狼疮性肾炎（LN）和肝炎（LH）相关。如对培养的人类细胞和鼠模型的研究所证明的，有证据表明抗RibP可能在LN和NPSLE中具有致病作用。尽管有大量证据，但与其他SLE自身抗体（例如抗Sm和抗dsDNA）相比，抗RibP尚未包括在SLE的分类标准中。一个重大挑战是用于检测抗RibP的检测方法的可变性，包括使用的抗原和诊断平台。这可能解释了SLE频率的显着变化（10-47％），并与SLE队列中报告的临床和人口统计学特征相关。我们进行了系统的文献综述和荟萃分析，以根据不同的RibP抗原和所用的测定平台，阐明其在SLE中的患病率，各种临床和血清学相关性。