Optogenetic-based neuromodulation tools is evolving for the basic neuroscience research in animals combining optical manipulation and electrophysiological recordings. However, current opto-electric integrated devices attaching on cerebral cortex for electrocorticogram (ECoG) still exist potential damage risks for both brain tissue and electrode, due to the mechanical mismatch and brain deformation. Here, we propose a stretchable opto-electric integrated neural interface by integrating serpentine-shaped electrodes and multisite micro-LEDs onto a hyperelastic substrate, as well as a serpentine-shaped metal shielding embedded in recording electrode for low-noise signal acquisition. The delicate structure design, ultrasoft encapsulation and independent fabrication followed by assembly are beneficial to the conformality, reliability and yield. In vitro accelerated deterioration and reciprocating tensile have demonstrated good performance and high stability. In vivo optogenetic activation of focal cortical areas of awaked mouse expressing Channelrhodopsin-2 is realized with simultaneous high-quality recording. We highlight the potential use of this multifunctional neural interface for neural applications.

中文翻译：

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灵活且可拉伸的光电神经接口，可用于体内低噪声皮层电图记录和神经调节。

基于光遗传学的神经调节工具正在发展为结合光学操作和电生理记录的动物基础神经科学研究。但是，由于机械失配和大脑变形，目前附着在大脑皮层上用于皮质电图（ECoG）的光电集成设备仍然存在对大脑组织和电极的潜在损害风险。在这里，我们通过将蛇形电极和多位微型LED集成到超弹性基板上，以及嵌入在记录电极中的蛇形金属屏蔽层中以获取低噪声信号，提出了一种可伸缩的光电集成神经接口。精致的结构设计，超软封装和独立制造，然后进行组装，有利于保形，可靠性和良率。体外加速劣化和往复拉伸表现出良好的性能和高稳定性。醒来的小鼠表达Channelrhodopsin-2的焦点皮层区域的体内光遗传学激活可以同时进行高质量的记录。我们强调了这种多功能神经接口在神经应用中的潜在用途。