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A kaurene-type novel phytotoxic substance in Wedelia chinensis
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.tetlet.2020.151600
Krishna Rany Das , Arihiro Iwasaki , Kiyotake Suenaga , Hisashi Kato-Noguchi

Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L at concentrations greater than 10-30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.



中文翻译:

中华草中的一种月桂烯型新型植物毒性物质

Wedelia chinensis已被广泛用作传统药物,并且已分离出几种生物活性化合物。我们调查了该物种的植物毒性特性和植物毒性物质。W. chinensis的甲醇水溶液提取物抑制了水芹根和芽的生长。然后通过监测抑制活性的几次色谱法纯化提取物,并分离出植物毒性物质。通过光谱数据确定该物质是一种新型的贝壳杉烯型化合物,wedelienone。Wedelienone抑制水芹和提摩太(Phleum pratense L)的生长,浓度大于10-30μM。这些结果表明,Wedelienone可能对提取物引起的植物毒性作用有贡献。

更新日期:2020-01-10
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