The objective of this study was to investigate the effects of freeze-dried muscadine grapes (FMG) or dealcoholized muscadine wine (DMW) on the symptoms and gut microbiota in mice with chronic colitis. C57BL/6J mice (female, 6-weeks old) were fed a control diet, control diet supplemented with FMG (7%, w/w) or DMW (5.5%, v/w). After 28 days, chronic colitis was induced by 3% DSS in drinking water for 7 days. FMG or DMW significantly reduced weight loss and other symptoms of chronic colitis (P ≤ 0.05). FMG or DMW increased fecal content of acetic acid and butyric acid in mice exposed to DSS. DSS treatment caused drastic dysbiosis in colon which were significantly improved by FMG and DMW in diet. DMW decreased the relative abundance of Clostridium and Akkermansia but increased the abundance of Roseburia, Anaerotruncus, and Coprococcus. This study suggested that muscadine gape or wine alleviate murine colitis and their activities were associated with reduced dysbiosis in colon.

这项研究的目的是调查冻干麝香葡萄（FMG）或脱醇麝香葡萄酒（DMW）对慢性结肠炎小鼠症状和肠道菌群的影响。给C57BL / 6J小鼠（雌性，6周龄）喂食对照饮食，补充有FMG（7％，w / w）或DMW（5.5％，v / w）的对照饮食。28天后，饮用水中3％DSS诱导慢性结肠炎持续7天。FMG或DMW显著减少失重和慢性结肠炎（症状P  ≤0.05）。FMG或DMW可增加暴露于DSS的小鼠粪便中乙酸和丁酸的含量。DSS治疗可导致结肠严重营养不良，饮食中FMG和DMW可显着改善DSS治疗。DMW降低了梭状芽胞杆菌和阿克曼虫的相对丰度但是增加了Roseburia，Anaerotruncus和Coprococcus的数量。这项研究表明，麝香葡萄球菌或葡萄酒可减轻小鼠结肠炎，其活动与结肠营养不良症的减轻有关。