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Emerging well-tailored nanoparticulate delivery system based on in situ regulation of the protein corona.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-01-10 , DOI: 10.1016/j.jconrel.2020.01.007 Zhenbao Li 1 , Yongqi Wang 1 , Jiaojiao Zhu 1 , Yachao Zhang 1 , Wenjing Zhang 1 , Mei Zhou 2 , Cong Luo 3 , Zegeng Li 4 , Biao Cai 5 , Shuangying Gui 1 , Zhonggui He 3 , Jin Sun 3
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-01-10 , DOI: 10.1016/j.jconrel.2020.01.007 Zhenbao Li 1 , Yongqi Wang 1 , Jiaojiao Zhu 1 , Yachao Zhang 1 , Wenjing Zhang 1 , Mei Zhou 2 , Cong Luo 3 , Zegeng Li 4 , Biao Cai 5 , Shuangying Gui 1 , Zhonggui He 3 , Jin Sun 3
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The protein corona significantly changes the nanoparticle (NP) identity both physicochemically and biologically, and in situ regulation of specific plasma protein adsorption on NP surfaces has emerged as a promising strategy for disease-targeting therapy. In the past decade, great progress in protein corona regulation has been achieved via surface chemistry-based nanomedicine development. This review first outlines the latest advances in bio-nano interactions, with special attention to factors that influence the protein corona, including NP physicochemical properties, the biological environment and the duration time. Second, NP surface chemistry strategies designed to inhibit and regulate protein corona formation are highlighted, with special emphasis on albumin, transferrin, apolipoprotein (apo) E, vascular endothelial growth factor (VEGF) and retinol binding protein 4 (RBP4). Finally, the current techniques used to characterize the protein corona are briefly discussed.
中文翻译：
基于蛋白质电晕的原位调节的新兴定制的纳米颗粒递送系统。
日冕蛋白在物理化学和生物学上均会显着改变纳米颗粒（NP）的身份，对NP表面特定血浆蛋白吸附的原位调节已成为一种有针对性的疾病靶向治疗策略。在过去的十年中，通过基于表面化学的纳米药物开发，蛋白质电晕调节取得了巨大进展。这篇综述首先概述了生物-纳米相互作用的最新进展，特别关注影响蛋白质电晕的因素，包括NP的理化性质，生物环境和持续时间。其次，重点介绍了旨在抑制和调节蛋白质电晕形成的NP表面化学策略，尤其着重于白蛋白，转铁蛋白，载脂蛋白（apo）E，血管内皮生长因子（VEGF）和视黄醇结合蛋白4（RBP4）。最后，简要讨论了用于表征蛋白质电晕的当前技术。
更新日期：2020-01-11
中文翻译：
基于蛋白质电晕的原位调节的新兴定制的纳米颗粒递送系统。
日冕蛋白在物理化学和生物学上均会显着改变纳米颗粒（NP）的身份，对NP表面特定血浆蛋白吸附的原位调节已成为一种有针对性的疾病靶向治疗策略。在过去的十年中，通过基于表面化学的纳米药物开发，蛋白质电晕调节取得了巨大进展。这篇综述首先概述了生物-纳米相互作用的最新进展，特别关注影响蛋白质电晕的因素，包括NP的理化性质，生物环境和持续时间。其次，重点介绍了旨在抑制和调节蛋白质电晕形成的NP表面化学策略，尤其着重于白蛋白，转铁蛋白，载脂蛋白（apo）E，血管内皮生长因子（VEGF）和视黄醇结合蛋白4（RBP4）。最后，简要讨论了用于表征蛋白质电晕的当前技术。
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