A supramolecular probe of cyanine dye for Pb2+ detection based on the recognition of a G-quadruplex from DNA duplexes,Analytical Methods

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A supramolecular probe of cyanine dye for Pb2+ detection based on the recognition of a G-quadruplex from DNA duplexes
Analytical Methods ( IF 2.7 ) Pub Date : 2020/01/10 , DOI: 10.1039/c9ay02446h
Lijia Yu _{1,

2,

3,

4} , Han Zhao _{1,

2,

3,

4} , Nannan Jing _{4,

5,

6,

7} , Xiaodong Shi _{1,

2,

3,

4} , Yinglin Zhang _{1,

2,

3,

4} , Chunguang Ding _{1,

2,

3,

4} , Yansong Zhang _{1,

2,

3,

4} , Jingguang Fan _{1,

2,

3,

4} , Yalin Tang _{8,

9,

10,

11,

12}

Affiliation

Herein, we carried out the supramolecular self-assembly of cyanine dye (MTC) for the transformation between duplex DNA and G-quadruplex (T30695) for the highly selective and sensitive recognition of Pb²⁺ ions via UV-vis spectroscopy. A specific duplex DNA (duplex-a) consisting of a Pb²⁺ aptamer and its part complementary strand was constructed, which could be unwound to single-strand DNA to form a G-quadruplex in the presence of Pb²⁺. The formed G-quadruplex could transform MTC H-aggregates into monomers, resulting in a specific recognition absorption signal.

中文翻译：

花青染料的超分子探针，用于基于DNA双链体的G-四链体的识别而检测Pb2 +

本文中，我们进行了花菁染料（MTC）的超分子自组装，以通过UV-vis光谱学对Pb ²⁺离子进行高度选择性和灵敏的识别，从而在双链DNA和G-四链体（T30695）之间进行转化。构建了由Pb ²⁺适体及其部分互补链组成的特异双链DNA（duplex-a），可以在Pb ²⁺存在的情况下将其解链为单链DNA以形成G-四链体。形成的G-四链体可以将MTC H-聚集体转化为单体，从而产生特定的识别吸收信号。

更新日期：2020-03-05

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