A new antibacterial peptide named pentaminomycin C was isolated from an extract of Streptomyces cacaoi subsp. cacaoi NBRC 12748T, along with a known peptide BE-18257A. Pentaminomycin C was determined to be a cyclic pentapeptide containing an unusual amino acid, Nδ-hydroxyarginine (5-OHArg), by a combination of ESI-MS and NMR analyses. The structure of pentaminomycin C was determined to be cyclo(-L-Leu-D-Val-L-Trp-L-5-OHArg-D-Phe-). Pentaminomycin C exhibited antibacterial activities against Gram-positive bacteria including Micrococcus luteus, Bacillus subtilis, and Staphylococcus aureus. The biosynthetic gene cluster for pentaminomycin C and BE-18257A was identified from the genome sequence data of S. cacaoi subsp. cacaoi.

中文翻译：

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可可链霉菌亚种中一种新的抗菌肽戊氨基霉素C的分离和结构测定。可可粉。

从可食链霉菌（Streptomyces cacaoi）亚种的提取物中分离出一种名为戊氨基霉素C的新抗菌肽。cacaoi NBRC 12748T，以及已知的肽BE-18257A。通过ESI-MS和NMR分析，确定戊糖霉素C为含有不寻常氨基酸Nδ-羟基精氨酸（5-OHArg）的环状五肽。确定戊氨基霉素C的结构为环（-L-Leu-D-Val-L-Trp-L-5-OHArg-D-Phe-）。戊氨霉素C对包括微球菌，枯草芽孢杆菌和金黄色葡萄球菌在内的革兰氏阳性细菌表现出抗菌活性。戊糖霉素C和BE-18257A的生物合成基因簇是从S.cacaoi亚种的基因组序列数据中鉴定的。可可粉。