BACKGROUND Heterogeneity of outcomes measured in trials to improve antimicrobial stewardship (AMS) in care homes has compromised quality of evidence. A core outcome set (COS) is needed to facilitate interpretation and synthesis of evidence in this area. AIM To determine outcomes deemed important by relevant stakeholders for interventions aimed at improving AMS in care homes, and to produce a refined list of outcomes that could be considered for use in future research. METHODS Semi-structured face-to-face or telephone interviews were conducted with key stakeholders. Outcomes reported in previous randomized controlled trials (RCTs) of AMS in care homes were included in a topic guide for interviews. Content analysis was undertaken to identify potential outcomes suggested by participants, followed by further review. FINDINGS Twenty-seven outcomes reported in RCTs were refined into a list of 12 overarching outcomes. Interviews with participants (six researchers, 31 healthcare professionals, and four family members of care home residents) identified 40 additional outcomes that were important to them. From these 52 outcomes, the total number of antimicrobials, the appropriateness of antimicrobial prescribing and adherence to guidelines were highlighted by most participants. After reviewing all 52 outcomes, a refined list of 14 outcomes potentially feasible for use in AMS trials in care homes was generated. CONCLUSION s: A number of potential outcomes for AMS in care homes, some of which had not been reported in previous studies, were identified. The refined list of 14 outcomes will be used in a future study to agree a COS for care home AMS trials.

中文翻译：

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疗养院的抗菌管理：对利益相关者重要的结果。

背景技术为改善疗养院中的抗菌素管理（AMS）而在试验中测得的结果的异质性损害了证据质量。需要一个核心结果集（COS）来促进该领域证据的解释和综合。目的确定相关利益相关者认为重要的结果，以进行旨在改善护理院中AMS的干预措施，并产生可考虑用于未来研究的结果的提炼清单。方法与主要利益相关者进行半结构化的面对面或电话访谈。先前在疗养院进行的AMS随机对照试验（RCT）报告的结果已纳入访谈主题指南。进行了内容分析以识别参与者建议的潜在结果，然后进行进一步审查。结果在RCT中报告的27个结果被提炼为12个总体结果的列表。与参与者（六名研究人员，31名医疗保健专业人员和四名养老院居民的家庭成员）的访谈确定了40项对他们来说很重要的额外结果。从这52个结果中，大多数参与者强调了抗菌药物的总数，抗菌药物处方的适当性和对指南的遵守。在回顾了所有52个结局后，生成了14个可能在护理院进行AMS试验中可能可行的结局的清单。结论：在护理院中，AMS有许多潜在的结果，其中一些在先前的研究中尚未被报道。精炼的14个结果清单将在以后的研究中使用，以同意COS用于护理院AMS试验。