BACKGROUND We determined the relationships among the subjective symptoms of sleep apnea and daytime sleepiness, depressive symptoms, and anxiety in adults with obstructive sleep apnea (OSA). METHODS We developed the Subjective Apnea Severity Questionnaire (SASQ) to measure subjective OSA symptoms during the night and on waking in the morning. Construct validity and reliability were assessed. The Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), and State Scale of State Trait Anxiety Inventory (STAI-S) were applied. Multiple linear regression analyses were performed, and the results were adjusted for several confounders. RESULTS A total of 337 OSA patients were included. The SASQ consists of eight items with three domains. Cronbach's α for the SASQ was 0.657. The mean SASQ score was 1.35 ± 0.59. Symptoms related to nocturnal breathing difficulties were associated with polysomnographic (PSG) respiratory parameters. In the adjusted models, total SASQ scores were associated with ESS scores but not with BDI or STAI-S scores. Unlike other symptom groups, nocturnal breathing difficulties tended toward a positive relationship with ESS scores (p = 0.076), but were negatively related to BDI scores (p = 0.003) and STAI-S scores (p = 0.012). Symptoms related to nocturnal awakening or morning waking were either positively related or unrelated to ESS, BDI, and STAI-S scores. CONCLUSIONS The subjective OSA symptoms measured via the SASQ were associated with daytime sleepiness in adults with OSA, but not with depressive symptoms or anxiety. Nocturnal breathing difficulties were positively related to daytime sleepiness, but negatively related to depressive symptoms and anxiety.

中文翻译：

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阻塞性睡眠呼吸暂停患者的主观夜间症状与抑郁症状和焦虑的关联与白天嗜睡的关联不同。

背景我们确定了成人阻塞性睡眠呼吸暂停（OSA）的睡眠呼吸暂停的主观症状与白天嗜睡，抑郁症状和焦虑之间的关系。方法我们开发了主观呼吸暂停严重程度调查表（SASQ），以在夜间和清晨醒来时测量主观OSA症状。对构建体的有效性和可靠性进行了评估。应用了爱泼华嗜睡量表（ESS），贝克抑郁量表（BDI）和状态特质焦虑量表状态量表（STAI-S）。进行了多个线性回归分析，并对多个混杂因素进行了调整。结果共纳入337例OSA患者。SASQ由具有三个域的八个项目组成。SASQ的Cronbachα为0.657。SASQ平均得分为1.35±0.59。与夜间呼吸困难有关的症状与多导睡眠图（PSG）呼吸参数有关。在调整后的模型中，总SASQ得分与ESS得分相关，但与BDI或STAI-S得分无关。与其他症状组不同，夜间呼吸困难与ESS评分呈正相关（p = 0.076），而与BDI评分（p = 0.003）和STAI-S评分（p = 0.012）呈负相关。与夜间醒来或清晨有关的症状与ESS，BDI和STAI-S得分呈正相关或不相关。结论通过SASQ测量的主观OSA症状与成人OSA的白天嗜睡有关，但与抑郁症状或焦虑无关。夜间呼吸困难与白天嗜睡呈正相关，