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The stability of blood Eosinophils in chronic obstructive pulmonary disease.
Respiratory Research ( IF 4.7 ) Pub Date : 2020-01-10 , DOI: 10.1186/s12931-020-1279-4
Gabriella H Long 1 , Thomas Southworth 1, 2 , Umme Kolsum 1, 2 , Gavin C Donaldson 3 , Jadwiga A Wedzicha 3 , Christopher E Brightling 4 , Dave Singh 1, 2
Affiliation  

Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.

中文翻译:

血液嗜酸性粒细胞在慢性阻塞性肺疾病中的稳定性。

血液嗜酸性粒细胞是慢性阻塞性肺疾病(COPD)中吸入皮质类固醇反应的预测生物标志物。我们使用COPDMAP队列中225名患者的全球慢性阻塞性肺疾病(GOLD)2019年嗜酸性粒细胞稳定性进行了研究,其阈值分别为<100、100- <300和≥300嗜酸性粒细胞/μL。血液嗜酸性粒细胞显示出良好的稳定性(rho:0.71,p <0.001,ICC 0.84),并且在1年时69.3%的患者仍处于同一嗜酸性粒细胞类别。嗜酸性粒细胞<100个细胞/μL的患者中有85.3%的患者计数稳定。使用GOLD 2019阈值,大多数血液嗜酸性粒细胞计数在1年内保持稳定。
更新日期:2020-01-11
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