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Absorbable suture can be effectively and safely used to close the mesenteric defect in a gastric bypass Sprague-Dawley rat model.
BMC Surgery ( IF 1.6 ) Pub Date : 2020-01-10 , DOI: 10.1186/s12893-019-0671-9 Libin Yao 1, 2 , Ponnie Robertlee Dolo 1, 2 , Yong Shao 1, 2 , Chao Li 1, 2 , Jason Widjaja 1, 2 , Jian Hong 1, 2 , Xiaocheng Zhu 1, 2
BMC Surgery ( IF 1.6 ) Pub Date : 2020-01-10 , DOI: 10.1186/s12893-019-0671-9 Libin Yao 1, 2 , Ponnie Robertlee Dolo 1, 2 , Yong Shao 1, 2 , Chao Li 1, 2 , Jason Widjaja 1, 2 , Jian Hong 1, 2 , Xiaocheng Zhu 1, 2
Affiliation
BACKGROUND
To observe if closing the mesenteric defect with absorbable sutures creates a safe adhesion compared to non-absorbable suture after Roux-en-Y gastric bypass.
METHODS
Rats were randomly assigned to 5 experimental groups according to the different suture materials used in closing the mesenteric defects (Peterson's space) after Roux-en-Y gastric bypass. Group A (control group), Group B (non-absorbable suture, Prolene suture), Group C (biological glue), Group D (non-absorbable suture, polyester suture) and Group E (absorbable suture). All rats were followed up for 8 weeks postoperatively and underwent laparotomy to observe the degree of adhesion and closure of the mesenteric defect.
RESULTS
No significant difference was found in the decrease in food intake and body weight among all groups. No internal hernia (IH) occurred in any group. The mesenteric defects of Group A remained completely visible without any closure or adhesion. Multiple gaps were found between the Prolene suture and the mesentery along the suture line in Group B. The mesenteric defects of Group C were complete closed with multiple adhesions of the small intestine and the greater omentum. The mesenteric defects in both Group D and Group E closed completely. The average adhesion scores in Group A and Group B were 0 and 0.33 ± 0.52 respectively. The average adhesion score in group C (3.83 ± 0.41) was higher than the other groups (p<0.05). The average adhesion scores in Group D and E were similar (3.17 ± 0.41 and 3.00 ± 0.00 respectively).
CONCLUSION
Absorbable suture created a safe adhesion score between the mesentery which was not inferior to non-absorbable sutures.
中文翻译：
可吸收缝合线可有效安全地用于闭合胃旁路Sprague-Dawley大鼠模型中的肠系膜缺损。
背景技术与Roux-en-Y胃旁路手术后的非吸收性缝合相比，观察用可吸收性缝合闭合肠系膜缺损是否能产生安全的粘连。方法根据Roux-en-Y胃旁路术后闭合肠系膜缺损（Peterson间隙）所使用的缝合线材料，将大鼠随机分为5个实验组。A组（对照组），B组（不可吸收缝合线，Prolene缝合线），C组（生物胶），D组（不可吸收缝合线，聚酯缝合线）和E组（可吸收缝合线）。对所有大鼠进行术后8周的随访，并进行剖腹手术以观察肠系膜缺损的粘连程度和闭合程度。结果各组之间食物摄入量和体重的减少均无显着差异。任何组均未发生内疝（IH）。A组的肠系膜缺陷保持完全可见，没有任何闭合或粘附。在B组的Prolene缝线和肠系膜之间沿缝线发现了多个缝隙。C组的肠系膜缺损完全闭合，小肠和大网膜被多次粘连。D组和E组的肠系膜缺损完全闭合。A组和B组的平均黏附评分分别为0和0.33±0.52。C组的平均黏附评分（3.83±0.41）高于其他组（p <0.05）。D组和E组的平均粘附力得分相似（分别为3.17±0.41和3.00±0.00）。结论可吸收缝合线在肠系膜之间建立了安全的粘附力评分，该评分不次于不可吸收缝合线。
更新日期：2020-01-11
中文翻译：
可吸收缝合线可有效安全地用于闭合胃旁路Sprague-Dawley大鼠模型中的肠系膜缺损。
背景技术与Roux-en-Y胃旁路手术后的非吸收性缝合相比，观察用可吸收性缝合闭合肠系膜缺损是否能产生安全的粘连。方法根据Roux-en-Y胃旁路术后闭合肠系膜缺损（Peterson间隙）所使用的缝合线材料，将大鼠随机分为5个实验组。A组（对照组），B组（不可吸收缝合线，Prolene缝合线），C组（生物胶），D组（不可吸收缝合线，聚酯缝合线）和E组（可吸收缝合线）。对所有大鼠进行术后8周的随访，并进行剖腹手术以观察肠系膜缺损的粘连程度和闭合程度。结果各组之间食物摄入量和体重的减少均无显着差异。任何组均未发生内疝（IH）。A组的肠系膜缺陷保持完全可见，没有任何闭合或粘附。在B组的Prolene缝线和肠系膜之间沿缝线发现了多个缝隙。C组的肠系膜缺损完全闭合，小肠和大网膜被多次粘连。D组和E组的肠系膜缺损完全闭合。A组和B组的平均黏附评分分别为0和0.33±0.52。C组的平均黏附评分（3.83±0.41）高于其他组（p <0.05）。D组和E组的平均粘附力得分相似（分别为3.17±0.41和3.00±0.00）。结论可吸收缝合线在肠系膜之间建立了安全的粘附力评分，该评分不次于不可吸收缝合线。
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