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Age-specific incidence of allergic and non-allergic asthma.
BMC Pulmonary Medicine ( IF 2.6 ) Pub Date : 2020-01-10 , DOI: 10.1186/s12890-019-1040-2
Johanna Pakkasela 1, 2 , Pinja Ilmarinen 3 , Jasmin Honkamäki 2 , Leena E Tuomisto 3 , Heidi Andersén 4 , Päivi Piirilä 5 , Hanna Hisinger-Mölkänen 6 , Anssi Sovijärvi 5 , Helena Backman 7 , Bo Lundbäck 8 , Eva Rönmark 7 , Hannu Kankaanranta 2, 3 , Lauri Lehtimäki 2, 9
Affiliation  

BACKGROUND Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in relation to allergy. The purpose of the study was to assess age-specific incidence of allergic and non-allergic asthma. METHODS Questionnaires were sent to 8000 randomly selected recipients aged 20-69 years in Finland in 2016. The response rate was 52.3% (n = 4173). The questionnaire included questions on e.g. atopic status, asthma and age at asthma diagnosis. Asthma was classified allergic if also a physician-diagnosed allergic rhinitis was reported. RESULTS The prevalence of physician-diagnosed asthma and allergic rhinitis were 11.2 and 17.8%, respectively. Of the 445 responders with physician-diagnosed asthma, 52% were classified as allergic and 48% as non-allergic. Median ages at diagnosis of allergic and non-allergic asthma were 19 and 35 years, respectively. Among subjects with asthma diagnosis at ages 0-9, 10-19, 20-29, 30-39, 40-49, 50-59 and 60-69 years, 70, 62, 58, 53, 38, 19 and 33%, respectively, were allergic. For non-allergic asthma, the incidence rate was lowest in children and young adults (0.7/1000/year). It increased after middle age and was highest in older age groups (2.4/1000/year in 50-59 years old). CONCLUSIONS The incidence of allergic asthma is highest in early childhood and steadily decreases with advancing age, while the incidence of non-allergic asthma is low until it peaks in late adulthood. After approximately 40 years of age, most of the new cases of asthma are non-allergic.

中文翻译:

过敏性和非过敏性哮喘的特定年龄段发病率。

背景技术过敏性哮喘的发作与儿童时期有很强的联系,但是只有少数研究分析了从儿童期到成年晚期与过敏症相关的哮喘发病率。这项研究的目的是评估过敏性和非过敏性哮喘的特定年龄段发病率。方法2016年,向芬兰8000名年龄在20-69岁的随机选择的接受调查者发送了问卷。答复率为52.3%(n = 4173)。该问卷包括关于过敏性状态,哮喘和哮喘诊断年龄的问题。如果还报告了医生诊断的变应性鼻炎,则将哮喘归为变应性。结果经医生诊断的哮喘和变应性鼻炎的患病率分别为11.2和17.8%。在445位经医生诊断为哮喘的响应者中,有52%被归类为过敏性,48%被归类为非过敏性。诊断为过敏性和非过敏性哮喘的中位年龄分别为19岁和35岁。在0-9岁,10-19岁,20-29岁,30-39岁,40-49岁,50-59岁和60-69岁的患有哮喘的受试者中,70%,62、58、53、38、19和33%分别是过敏的。对于非过敏性哮喘,儿童和年轻人的发生率最低(0.7 / 1000 /年)。它在中年以后增加,并且在老年组中最高(50/59岁年龄组为2.4 / 1000 /年)。结论过敏性哮喘的发生率在儿童早期最高,并且随着年龄的增长而稳步下降,而非过敏性哮喘的发生率一直很低,直到成年后期达到高峰。大约40岁以后,大多数新的哮喘病例都是非过敏性的。在0-9岁,10-19岁,20-29岁,30-39岁,40-49岁,50-59岁和60-69岁的患有哮喘的受试者中,70%,62、58、53、38、19和33%分别是过敏的。对于非过敏性哮喘,儿童和年轻人的发生率最低(0.7 / 1000 /年)。它在中年以后增加,并且在老年组中最高(50/59岁年龄组为2.4 / 1000 /年)。结论过敏性哮喘的发生率在儿童早期最高,并且随着年龄的增长而稳步下降,而非过敏性哮喘的发生率一直很低,直到成年后期达到高峰。大约40岁以后,大多数新的哮喘病例都是非过敏性的。在0-9岁,10-19岁,20-29岁,30-39岁,40-49岁,50-59岁和60-69岁的患有哮喘的受试者中,70%,62、58、53、38、19和33%分别是过敏的。对于非过敏性哮喘,儿童和年轻人的发生率最低(0.7 / 1000 /年)。它在中年以后增加,并且在老年组中最高(50/59岁年龄组为2.4 / 1000 /年)。结论过敏性哮喘的发生率在儿童早期最高,并且随着年龄的增长而稳步下降,而非过敏性哮喘的发生率一直很低,直到成年后期达到高峰。大约40岁以后,大多数新的哮喘病例都是非过敏性的。儿童和年轻人的发生率最低(0.7 / 1000 /年)。它在中年以后增加,并且在老年组中最高(50/59岁年龄组为2.4 / 1000 /年)。结论过敏性哮喘的发生率在儿童早期最高,并且随着年龄的增长而稳步下降,而非过敏性哮喘的发生率一直很低,直到成年后期达到高峰。大约40岁以后,大多数新的哮喘病例都是非过敏性的。儿童和年轻人的发生率最低(0.7 / 1000 /年)。它在中年以后增加,并且在老年组中最高(50/59岁年龄组为2.4 / 1000 /年)。结论过敏性哮喘的发生率在儿童早期最高,并且随着年龄的增长而稳步下降,而非过敏性哮喘的发生率一直很低,直到成年后期达到高峰。大约40岁以后,大多数新的哮喘病例都是非过敏性的。
更新日期:2020-01-11
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