BACKGROUND We aimed to investigate the effect of early-age (prenatal, infant, and childhood) trauma on adulthood alcohol use disorder. METHODS A total number of 1534 subjects who were born and live in the city of Tangshan were selected. The subjects were divided into three age groups. General demographic data, conditions of the mothers during pregnancy, and condition of the babies at birth, were collected. The diagnosis of alcohol use disorder was based on Structured Clinical Interviews for DSM-IV Axis Disorders (patient version) (SCID). The childhood trauma questionnaire short form (CTQ-SF) [1] and the Lifetime of Experience Questionnaire (LTE-Q) [2] were used to evaluate stress in childhood and adulthood, respectively. RESULTS Only male subjects were diagnosed with lifelong alcohol abuse and alcohol dependence. There was no statistically significant difference in the prevalence of lifetime alcohol use disorder (X2 = 4.480, P = 0.345), current alcohol abuse, and current alcohol dependence among the three groups (X2abuse = 2.177, X2depedence = 2.198, P > 0.05). However, higher prevalence of lifetime alcohol use disorders was found in group with higher scores of CTQ (X2 = 9.315, P = 0.009), emotional abuse (X2 = 8.025, P = 0.018), physical abuse (X2 = 20.4080, P < 0.001), but not in the group with higher scores of emotional neglect (X2 = 1.226, P = 0.542), sexual abuse (X2 = 2.779, P = 0.249), physical neglect (X2 = 3.978, P = 0.137), LTE-Q (X2 = 5.415, P = 0.067), and PSQI (X2 = 5.238, P = 0.073). Protective factor for alcohol abuse for men was identified to be heavy drinking (OR = 0.085, 95%CI: 0.011-0.661), and the risk factors for alcohol abuse were identified to be frequent drinking (OR = 2.736, 95%CI: 1.500, 4.988), and consumption of low liquor (OR = 2.563, 95%CI: 1.387, 4.734). Risk factors for alcohol dependence in males were identified to be consumption of low liquor (OR = 5.501, 95%CI: 2.004, 15.103), frequent drinking (OR = 2.680, 95%CI: 1.164, 6.170), and childhood physical abuse (OR = 2.310, 95% CI: 1.026, 5.201). CONCLUSION Traumatic experience during infant and prenatal periods does not have a strong statistical correlation with alcohol use disorders for male adults. However, subjects with high CTQ scores, experience of emotional abuse and physical abuse show a statistically higher prevalence of lifetime alcohol use disorders. Several risk factors including consumption of low liquor, frequent drinking, and childhood physical abuse contribute to alcohol dependence in male adults.

中文翻译：

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评价儿童创伤经历是成年后酒精使用障碍的危险因素。

背景技术我们旨在调查早期（产前，婴儿和儿童期）创伤对成年酒精使用障碍的影响。方法选择唐山市出生和生活的1534名受试者。受试者分为三个年龄组。收集了总体人口统计数据，怀孕期间母亲的状况以及出生时婴儿的状况。酒精使用障碍的诊断基于对DSM-IV轴异常（患者版本）（SCID）的结构化临床访谈。儿童创伤问卷（CTQ-SF）[1]和生命周期问卷（LTE-Q）[2]分别用于评估儿童期和成年期的压力。结果只有男性受试者被诊断为终身酗酒和酒精依赖。三组中终生饮酒障碍的患病率（X2 = 4.480，P = 0.345），目前的酒精滥用和当前的酒精依赖没有统计学差异（X2滥用= 2.177，X2依赖= 2.198，P> 0.05）。但是，在CTQ得分较高（X2 = 9.315，P = 0.009），情感虐待（X2 = 8.025，P = 0.018），身体虐待（X2 = 20.4080，P <0.001）的人群中，终生饮酒障碍的患病率更高。 ），但在情绪疏忽（X2 = 1.226，P = 0.542），性虐待（X2 = 2.779，P = 0.249），身体疏忽（X2 = 3.978，P = 0.137），LTE-Q得分较高的人群中没有（X2 = 5.415，P = 0.067）和PSQI（X2 = 5.238，P = 0.073）。男性酗酒的保护因素被确定为酗酒（OR = 0.085，95％CI：0.011-0.661），酒精滥用的危险因素被确定为经常饮酒（OR = 2.736，95％CI：1.500，4.988）和低度饮酒（OR = 2.563，95％CI：1.387，4.734）。男性酒精依赖的危险因素被确定为低度饮酒（OR = 5.501，95％CI：2.004，15.103），频繁饮酒（OR = 2.680，95％CI：1.164，6.170）和儿童身体虐待（ OR = 2.310，95％CI：1.026，5.201）。结论婴儿和产前的创伤经历与男性成年人饮酒障碍没有明显的统计学相关性。然而，具有较高CTQ分数，情感虐待和身体虐待经历的受试者，其一生饮酒障碍的患病率在统计学上较高。若干危险因素包括低度饮酒，频繁饮酒，