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Kidney function and nephrotoxic drug use among older home-dwelling persons with or without diabetes in Finland.
BMC Nephrology ( IF 2.2 ) Pub Date : 2020-01-10 , DOI: 10.1186/s12882-020-1684-4
Marjo Heinjoki 1 , Merja Karjalainen 2, 3 , Juha Saltevo 4 , Miia Tiihonen 1 , Maija Haanpää 5, 6 , Hannu Kautiainen 7, 8 , Pekka Mäntyselkä 2, 8
Affiliation  

BACKGROUND Due to these changes in kidney function, aging kidneys are more prone to drug-induced impairments in renal properties. Diabetes has been associated with the declined kidney function and an elevated risk of renal failure. The aim of this study is to compare kidney function and potentially nephrotoxic drug use among home-dwelling older persons with or without diabetes. METHODS A total of 259 persons with and 259 persons without diabetes and aged ≥65 years were randomly selected to participate in a health examination with complete data gathered from 363 individuals (187 with diabetes and 176 without diabetes). The estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Each participant was categorized based on the nephrotoxic profile of their medications. RESULTS There were no differences in mean eGFR values (77.5 ± 18.8 vs. 80.5 ± 14.8 ml/min/1.73m2, p = 0.089) or in the proportion of participants with eGFR < 60 ml/min/1.73m2 among persons with diabetes (16% vs. 10%, p = 0.070), compared to persons without diabetes. Potentially nephrotoxic drug use was similar between the groups. The mean number of potentially nephrotoxic drugs was 1.06 ± 0.88 in those with and 0.97 ± 1.05 in those without diabetes (p = 0.39). CONCLUSIONS The kidney function of older persons with diabetes does not differ from that of older persons without diabetes and furthermore potentially nephrotoxic drug use seem to play only a minor role in the decline in kidney function among home-dwelling persons in the Inner-Savo district.

中文翻译:

芬兰患有或不患有糖尿病的老年人的肾脏功能和肾毒性药物的使用。

背景技术由于肾功能的这些变化,衰老的肾脏更易于引起药物诱导的肾特性损害。糖尿病与肾功能下降和肾衰竭风险升高有关。这项研究的目的是比较患有或没有糖尿病的家庭老年人的肾功能和潜在肾毒性药物的使用。方法随机选择259名患有糖尿病的人和259名≥65岁的无糖尿病人参加健康检查,并从363名患者(187名糖尿病患者和176名非糖尿病患者)中收集完整数据。使用CKD-EPI公式计算估计的肾小球滤过率(eGFR)。根据参加者的肾毒性概况对其进行分类。结果糖尿病患者的平均eGFR值(77.5±18.8 vs. 80.5±14.8 ml / min / 1.73m2,p = 0.089)或在糖尿病患者中eGFR <60 ml / min / 1.73m2的参与者比例没有差异(与没有糖尿病的人相比,分别为16%和10%,p = 0.070)。两组之间潜在的肾毒性药物使用相似。有糖尿病的潜在肾毒性药物的平均数为1.06±0.88,而无糖尿病的则为0.97±1.05(p = 0.39)。结论患有糖尿病的老年人的肾脏功能与没有糖尿病的老年人没有什么不同,此外,在内萨瓦地区的居家患者中,肾毒性药物的潜在使用似乎在肾功能下降中仅起很小的作用。089)或糖尿病患者中eGFR <60 ml / min / 1.73m2的参与者比例(16%vs. 10%,p = 0.070)。两组之间潜在的肾毒性药物使用相似。有糖尿病的潜在肾毒性药物的平均数为1.06±0.88,而无糖尿病的则为0.97±1.05(p = 0.39)。结论患有糖尿病的老年人的肾脏功能与没有糖尿病的老年人没有什么不同,此外,在内萨瓦地区的居家患者中,肾毒性药物的潜在使用似乎在肾功能下降中仅起很小的作用。089)或糖尿病患者中eGFR <60 ml / min / 1.73m2的参与者比例(16%vs. 10%,p = 0.070)。两组之间潜在的肾毒性药物使用相似。有糖尿病的患者的潜在肾毒性药物的平均数为1.06±0.88,而无糖尿病的患者为0.97±1.05(p = 0.39)。结论患有糖尿病的老年人的肾脏功能与没有糖尿病的老年人没有什么不同,此外,在内萨瓦地区的居家患者中,肾毒性药物的潜在使用似乎在肾功能下降中仅起很小的作用。有糖尿病的潜在肾毒性药物的平均数为1.06±0.88,而无糖尿病的则为0.97±1.05(p = 0.39)。结论患有糖尿病的老年人的肾脏功能与没有糖尿病的老年人没有什么不同,此外,在内萨瓦地区的居家患者中,肾毒性药物的潜在使用似乎在肾功能下降中仅起很小的作用。有糖尿病的潜在肾毒性药物的平均数为1.06±0.88,而无糖尿病的则为0.97±1.05(p = 0.39)。结论患有糖尿病的老年人的肾脏功能与没有糖尿病的老年人没有什么不同,此外,在内萨瓦地区的居家患者中,肾毒性药物的潜在使用似乎在肾功能下降中仅起很小的作用。
更新日期:2020-01-11
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