Synthesis of 5‐amino‐1,3,4‐thiadiazoles containing dithiocarbamate groups,Journal of Heterocyclic Chemistry

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Synthesis of 5‐amino‐1,3,4‐thiadiazoles containing dithiocarbamate groups
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-01-10 , DOI: 10.1002/jhet.3841
Maryam Khoshdoun ₁ , Salman Taheri ₁ , Parandis Daneshgar ₂ , Hamid R. Jamshidi ₂ , Azim Ziyaei Halimehjani ₃

Affiliation

Synthesis of alkyl ((5‐[alkylamino]‐1,3,4‐thiadiazol‐2‐yl)methyl)carbamodithioates via the reaction of glycine‐based dithiocarbamates with thiosemicarbazides in the presence of POCl₃ in ethanol is disclosed. The main advantages of this method including the use of ethanol as solvent, no need to column chromatography for purification and high to excellent yields of products are noteworthy.

中文翻译：

含二硫代氨基甲酸酯基团的5-氨基-1,3,4-噻二唑的合成

公开了在乙醇中存在POCl ₃的情况下，基于甘氨酸的二硫代氨基甲酸酯与硫代半氨基叠氮化物的反应，合成（（5- [烷基氨基] -1,3,4-噻二唑-2-基）甲基）氨基甲酰胺基硫代甲烷。值得注意的是，该方法的主要优点包括使用乙醇作为溶剂，无需进行柱色谱纯化即可获得高产量。

更新日期：2020-01-11

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