Synthesis and antifungal activities of 3,5‐diphenyl‐7‐amino‐[1,3]‐thiazolo[3,2‐a]pyrimidine‐6‐nitrile derivatives,Journal of Heterocyclic Chemistry

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Synthesis and antifungal activities of 3,5‐diphenyl‐7‐amino‐[1,3]‐thiazolo[3,2‐a]pyrimidine‐6‐nitrile derivatives
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-01-10 , DOI: 10.1002/jhet.3863
Susanta Kumar Borthakur ₁ , Pabitra Kumar Kalita ₂ , Sukanya Borthakur _{3,

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Affiliation

A series of novel 3,7‐diphenyl‐7‐amino[1,3]‐thiazolo[3,2‐a]pyrimidine‐6‐nitrile derivatives 3 were synthesized by refluxing 2‐amino‐4‐phenyl‐1,3‐thiazole 1 and arylidinemalononitrile 2 in propanol using NaOH as catalyst. Various synthesized products were characterized by ¹H NMR, mass spectrometry (MS), infrared (IR), and elemental analysis. Antifungal activities of the synthesized compounds were done by testing against Rhizoctonia solani and Drechslera orazae, two fungal pathogens causing diseases on rice crops.

中文翻译：

3,5-二苯基-7-氨基-[1,3]-噻唑并[3,2-a]嘧啶-6-腈衍生物的合成和抗真菌活性

通过回流2-氨基-4-苯基-1,3-合成了一系列新颖的3,7-二苯基-7-氨基[1,3]-噻唑并[3,2 - a ]嘧啶-6-腈衍生物3。丙醇中的噻唑1和芳基丙二腈2（使用NaOH作为催化剂）。各种合成产物通过¹ H NMR，质谱（MS），红外（IR）和元素分析进行表征。合成化合物的抗真菌活性是通过针对两种引起水稻作物病害的真菌病原体solani Rhizoctonia solani和Drechslera orazae进行测试的。

更新日期：2020-01-11

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