INTRODUCTION Transplant of fetal ventral mesencephalic tissue into the striatum of Parkinson's disease (PD) patients has been performed to increase dopamine production and stimulate neuronal regeneration. Analysis of fetal graft tissue at autopsy has demonstrated 6 cases of α-synuclein pathology in PD patients, one case with both α-synuclein and tau pathology in a PD patient, and two cases of tau pathology within a Huntington's Disease patient. METHODS A 49 year old man with PD underwent bilateral fetal ventral mesencephalic cell transplants into the striatum. Autopsy at age 70 included immunohistochemical staining of host and graft tissue with antibodies to phosphorylated α-synuclein and phosphorylated tau protein. RESULTS Autopsy confirmed the diagnosis of PD. Immunohistochemical staining of graft tissue demonstrated frequent neuronal perikaryal inclusions of phosphorylated α -synuclein and tau in the left graft only. CONCLUSION Speculations on the formation of pathology include: 1) α-synuclein and tau pathology spread from host to the graft in a neuron-neuron manner. 2) The nature of the fetal cells themselves, or transplantation process, may render fetal tissue more susceptible to the spontaneous generation of pathology. 3) Factors within host environment caused native tau and α-synuclein in fetal tissue graft to become phosphorylated.

中文翻译：

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尸体解剖时胎儿移植物组织中tau和α-突触核蛋白病理学的共存：一例。

引言已经进行了将胎儿腹侧中脑组织移植到帕金森氏病（PD）患者的纹状体中，以增加多巴胺的产生并刺激神经元的再生。尸检时对胎儿移植物组织的分析表明，PD患者中有6例α-突触核蛋白病理，PD患者中有1例同时具有α-突触核蛋白和tau病理，在Huntington病患者中有2例tau病理。方法一名49岁的PD患儿接受了双侧胎儿腹侧中脑细胞移植到纹状体中。70岁时的尸检包括用抗磷酸化α-突触核蛋白和磷酸化tau蛋白的抗体对宿主和移植组织进行免疫组织化学染色。结果尸检证实了PD的诊断。移植物组织的免疫组织化学染色显示，仅左移植物中磷酸化的α-突触核蛋白和tau的神经元周围神经包涵体频繁。结论关于病理形成的推测包括：1）α-突触核蛋白和tau病理以神经元-神经元的方式从宿主传播到移植物。2）胎儿细胞本身的性质或移植过程可能使胎儿组织更容易自发产生病理。3）宿主环境中的因素导致胎儿组织移植物中的天然tau和α-突触核蛋白被磷酸化。2）胎儿细胞本身的性质或移植过程可能使胎儿组织更容易自发产生病理。3）宿主环境中的因素导致胎儿组织移植物中的天然tau和α-突触核蛋白被磷酸化。2）胎儿细胞本身的性质或移植过程可能使胎儿组织更容易自发产生病理。3）宿主环境中的因素导致胎儿组织移植物中的天然tau和α-突触核蛋白被磷酸化。