We read with interest the research letter by Raychaudhuri et al , which examines the frequencies of cytokine producing CD4+ memory T cells in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) synovial fluid mononuclear cells (SFMC) compared with peripheral blood mononuclear cells (PBMC).1 The authors examined the frequencies of single cytokine-producing T cells, specifically interleukin (IL)-17A+, IL-22+, tumour necrosis factor (TNF)+, interferon gamma (IFNγ)+ or IL-23R+ and report that Th17 cells are enriched in PsA SFMC, while RA is skewed to a Th1-like profile. In our previous publication, Wade et al ,2 we reported the frequencies of both single cytokine-producing and multiple cytokine (polyfunctional)-producing T cells, in addition to the frequencies of Th1, Th17 and exTh17 cells by using the Th17 lineage marker CD161. In our study, however, we reported these findings in synovial tissue biopsies from PsA patients, as opposed …

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回应：Raychaudhuri 等人的“银屑病关节炎滑膜中的多功能 TEM 细胞偏向 Th17 细胞”

我们感兴趣地阅读了 Raychaudhuri 等人的研究信函，该信函检查了银屑病关节炎 (PsA) 和类风湿性关节炎 (RA) 滑液单核细胞 (SFMC) 与外周血单核细胞 (PBMC) 中产生细胞因子的 CD4+ 记忆 T 细胞的频率).1 作者检查了单个产生细胞因子的 T 细胞的频率，特别是白细胞介素 (IL)-17A+、IL-22+、肿瘤坏死因子 (TNF)+、干扰素 γ (IFNγ)+ 或 IL-23R+，并报告说Th17 细胞富含 PsA SFMC，而 RA 则偏向于 Th1 样谱。在我们之前的出版物 Wade 等人 2 中，我们通过使用 Th17 谱系标记 CD161 报告了产生单个细胞因子和产生多个细胞因子（多功能）的 T 细胞的频率，以及 Th1、Th17 和 exTh17 细胞的频率. 在我们的研究中，