Crokonoid A (1), a highly rearranged diterpenoid featuring a dual-bridged tricyclo[4.4.1.11,4]dodecane-2,11-dione ring system and its two possible ent-kaurene diterpenoid precursors (2 and 3), was isolated and structurally characterized by solid data from Croton kongensis. Compound 1 exhibited significant cytotoxicity against HL-60 and A-549 cell lines with IC50 values of 1.24 ± 0.56 and 1.92 ± 0.60 μM, respectively.

中文翻译：

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Crokonoids AC，一种高度重排和双桥的螺二萜和两个其他来自Croton kongensis的二萜。

分离并以双桥三环[4.4.1.11,4]十二烷-2,11-二酮环系统及其两种可能的对映体-天花烯二萜类前体（2和3）为代表的高度重排的二萜类化合物Cronokoid A（1）被分离并分离。结构上以巴豆科豆的实证数据为特征。化合物1对HL-60和A-549细胞系表现出明显的细胞毒性，IC50值分别为1.24±0.56和1.92±0.60μM。