当前位置: X-MOL 学术Org. Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
CF3SO2Na-Mediated, UV-Light-Induced Friedel-Crafts Alkylation of Indoles with Ketones/Aldehydes and Bioactivities of Products.
Organic Letters ( IF 4.9 ) Pub Date : 2020-01-08 , DOI: 10.1021/acs.orglett.9b04272
Tianbao Yang 1 , Huiai Lu 2 , Yixuan Shu 2 , Yifeng Ou 1 , Ling Hong 2 , Chak-Tong Au 3 , Renhua Qiu 1
Affiliation  

A concise, one-step route to produce 3,3'-diindolylmethanes (DIMs) from simple indoles and ketones or aldehydes is reported. The key step is the ready formation of indole derivatives that involves the in situ conversion of CF3SO2Na reagent to ·CF3 under oxygen or air (1.0 atm) and UV irradiation. It is disclosed that most of the obtained DIMs show anticancer activities in human bladder cancer cell lines EJ and T24.

中文翻译:

CF3SO2Na介导的紫外光诱导的吲哚与酮/醛的弗瑞德-克拉夫茨烷基化和产物的生物活性。

据报道,一种简单的一步法可以从简单的吲哚,酮或醛生产3,3'-二吲哚甲烷(DIM)。关键步骤是立即形成吲哚衍生物,其中涉及在氧气或空气(1.0大气压)和紫外线照射下将CF3SO2Na试剂原位转化为·CF3。公开了大多数获得的DIM在人膀胱癌细胞系EJ和T24中显示出抗癌活性。
更新日期:2020-01-09
down
wechat
bug