Stereoselective Synthesis of β-Amino Ynones by the Addition of Alkynones to Nonracemic Sulfinimines: Formal Total Synthesis of l-Xylo and l-Arabino Phytosphingosines.,The Journal of Organic Chemistry

当前位置： X-MOL 学术 › J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Stereoselective Synthesis of β-Amino Ynones by the Addition of Alkynones to Nonracemic Sulfinimines: Formal Total Synthesis of l-Xylo and l-Arabino Phytosphingosines.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-01-16 , DOI: 10.1021/acs.joc.9b02938
Polimera Obula Reddy ₁ , Arava Amaranadha Reddy ₁ , Kavirayani R Prasad ₁

Affiliation

The addition of silyl enol ethers obtained from ynones to sulfinimines furnished the corresponding β-sulfinamido ynones in a very good yield and diastereoselectivity. The formed ynones serve as precursors amenable for the synthesis of bioactive compounds. This has been illustrated in the synthesis of l-xylo and l-arabino phytosphingosines.

中文翻译：

通过将炔烃加到非外消旋亚磺胺上的立体选择性合成β-氨基壬烯：l-木糖和l-阿拉伯植物鞘氨醇的正式全合成。

将由炔酮得到的甲硅烷基烯醇醚加到亚磺胺中，以非常好的收率和非对映选择性提供了相应的β-亚磺酰胺基炔酮。形成的炔酮用作适于合成生物活性化合物的前体。在1-xylo和1-阿拉伯糖基植物鞘氨醇的合成中已经说明了这一点。

更新日期：2020-01-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文