In order to expand the application in biomedical field of bio-derived polymers it is imperative that the issues related to their surface properties be addressed. Here we explore the approach of simultaneous radical polymerization to modify the surface properties of chitosan by grafting/crosslinking with poly(N-vinyl pyrrolidone) (PNVP)/α,ω-bis (methacryloyloxy-poly(ethylene glycol) (M-PEG) in the presence of potassium persulfate. The structure of the resultant copolymer membranes was proved by Attenuated Total Reflectance-Fourier Transform Infrared Spectrometry. Scanning Electron Microscopy and Atomic Force Microscopy revealed the crosslinked copolymer membranes are porous materials with pore dimension, distribution and shape depending on the content of vinyl sequences. In addition, was revealed that the presence of vinyl crosslinked sequences linked to CS is disturbing the thermodynamic equilibrium conformation of CS. As a consequence, the ordering of CS chains into crystalline domains is reduced and the planes giving rise to the diffraction peaks are modified. Thus, the resultant copolymer membranes, depending by the weight ratio PNVP/M-PEG, became more amorphous. As a result of the crosslinking, the copolymer membranes were characterized by a smaller water swelling degree (about 300%) as compared with neat chitosan membrane (700%). The thermo-oxidative data have revealed an enhancement of the thermal stability of CS by crosslinking with PNVP/M-PEG copolymers. The water contact angles of the copolymer membranes proved to be more water wettable as compared to neat chitosan membrane.

为了扩大生物衍生的聚合物在生物医学领域的应用，必须解决与它们的表面性质有关的问题。在这里，我们探索了同时自由基聚合通过与聚（N）接枝/交联来改变壳聚糖表面性能的方法。变得更加无定形。交联的结果是，与纯壳聚糖膜（700％）相比，共聚物膜的水溶胀度较小（约300％）。热氧化数据表明通过与PNVP / M-PEG共聚物交联可以增强CS的热稳定性。与纯壳聚糖膜相比，共聚物膜的水接触角被证明具有更高的水可湿性。