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Gram-Scale Synthesis of the Co(nmp)2 Catalyst to Prepare trans-2,5-Disubstituted Tetrahydrofurans by the Aerobic Oxidative Cyclization of Pent-4-en-1-ols
Synthesis ( IF 2.2 ) Pub Date : 2020-01-08 , DOI: 10.1055/s-0039-1690730 Barbora Morra , Nicholas A. Morra , Daniel G. MacDonald , Brian L. Pagenkopf 1
Synthesis ( IF 2.2 ) Pub Date : 2020-01-08 , DOI: 10.1055/s-0039-1690730 Barbora Morra , Nicholas A. Morra , Daniel G. MacDonald , Brian L. Pagenkopf 1
Affiliation
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Co(nmp)2 is an efficient catalyst for the aerobic oxidative cyclization of pent-4-en-1-ols to give 5-hydroxymethyl trans-tetrahydrofurans (THFs) as single diastereomers in high yield. The trans-THF pharmacophore is of interest because it is found in many biologically active natural products. The three-step synthesis of Co(nmp)2 described here gives the catalyst as a fine powder in 80–85% overall yield on 10-gram scale. The use of the catalyst in a representative oxidative cyclization is also described.
中文翻译：
革兰氏合成的Co（nmp）2催化剂通过Pent-4-en-1-ols的好氧氧化环化反应制备反式2,5-二取代的四氢呋喃
Co（nmp）2是有效的催化剂，可对戊-4-烯-1-醇进行好氧氧化环化，以高收率得到作为单个非对映异构体的5-羟甲基反式-四氢呋喃（THF）。该反式，因为它在许多生物活性天然产物发现-THF药效感兴趣。本文所述的Co（nmp）2的三步合成法以10克规模的总产率80-85％的形式得到了细粉状催化剂。还描述了催化剂在代表性氧化环化中的用途。
更新日期：2020-01-09
中文翻译：
革兰氏合成的Co（nmp）2催化剂通过Pent-4-en-1-ols的好氧氧化环化反应制备反式2,5-二取代的四氢呋喃
Co（nmp）2是有效的催化剂，可对戊-4-烯-1-醇进行好氧氧化环化，以高收率得到作为单个非对映异构体的5-羟甲基反式-四氢呋喃（THF）。该反式，因为它在许多生物活性天然产物发现-THF药效感兴趣。本文所述的Co（nmp）2的三步合成法以10克规模的总产率80-85％的形式得到了细粉状催化剂。还描述了催化剂在代表性氧化环化中的用途。
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