A procalcitonin photoelectrochemical immunosensor: NCQDs and Sb2S3 co-sensitized hydrangea-shaped WO3 as a matrix through a layer-by-layer assembly,New Journal of Chemistry

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A procalcitonin photoelectrochemical immunosensor: NCQDs and Sb2S3 co-sensitized hydrangea-shaped WO3 as a matrix through a layer-by-layer assembly
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020/01/09 , DOI: 10.1039/c9nj06118e
Xin Liu _{1,

2,

3,

4,

5} , Chunzhu Bao _{1,

2,

3,

4,

5} , Xinrong Shao _{1,

2,

3,

4,

5} , Yong Zhang _{1,

2,

3,

4,

5} , Nuo Zhang _{1,

2,

3,

4,

5} , Xu Sun _{1,

2,

3,

4,

5} , Dawei Fan _{1,

2,

3,

4,

5} , Qin Wei _{1,

2,

3,

4,

5} , Huangxian Ju _{1,

2,

3,

4,

5}

Affiliation

Using nitrogen-doped carbon quantum dots (NCQDs) and antimony trisulfide (Sb₂S₃) to co-sensitize hydrangea-shaped tungsten trioxide (WO₃), a novel photoelectrochemical (PEC) immunosensor was constructed to sensitively detect procalcitonin (PCT). WO₃ possessed a three-dimensional structure with uniform size and large surface area on the indium tin oxide (ITO) electrode. NCQDs with abundant carboxy groups and excitation-independent PEC behavior were modified on the surface of the WO₃ coating to enhance photochemical activity. Hence, the hydrangea-shaped WO₃/NCQDs/Sb₂S₃ composite was obtained by modifying NCQDs and well-crystallized Sb₂S₃ nanoparticles on WO₃ through a layer-by-layer assembly. It is worth noting that the photoelectric signal of WO₃/NCQDs/Sb₂S₃ was about 8 times that of pure WO₃ under visible light excitation. Moreover, the PEC immunosensor showed a large-scale response (0.001–100 ng mL⁻¹) and a low detection limit (0.42 pg mL⁻¹) under the best experimental conditions. This PEC immunosensor has advantages such as simplicity, facile fabrication, high sensitivity and strong stability, which have good research value in the analysis and detection of disease biomarkers.

中文翻译：

降钙素原光电化学免疫传感器：NCQDs和Sb2S3通过层到层组件共敏化绣球形WO3作为基质

使用氮掺杂的碳量子点（NCQDs）和三硫化锑（Sb ₂ S ₃）对八仙花形三氧化钨（WO ₃）进行共敏化，构建了一种新型光电化学（PEC）免疫传感器来灵敏地检测降钙素原（PCT）。WO ₃在氧化铟锡（ITO）电极上具有三维结构，具有均匀的尺寸和较大的表面积。在WO ₃涂层表面改性了具有丰富羧基和不依赖激发的PEC行为的NCQD，以增强光化学活性。因此，绣球形状的WO ₃ / NCQDs / Sb ₂ S ₃通过修饰NCQD和WO ₃上结晶良好的Sb ₂ S ₃纳米粒子，通过逐层组装获得复合材料。值得注意的是，在可见光激发下，WO ₃ / NCQDs / Sb ₂ S ₃的光电信号约为纯WO _3的8倍。此外，PEC免疫传感器显示出大规模反应（0.001–100 ng mL ^-1）和低检测限（0.42 pg mL ^-1））在最佳实验条件下。该PEC免疫传感器具有简单，易于制造，灵敏度高，稳定性强等优点，在疾病生物标志物的分析检测中具有良好的研究价值。

更新日期：2020-02-12

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