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Hybridization of carboxymethyl chitosan with MOFs to construct recyclable, long-acting and intelligent antibacterial agent carrier.
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.carbpol.2020.115848 Guohuan Huang 1 , Yanming Li 2 , Zhimei Qin 1 , Qun Liang 1 , Chuanhui Xu 1 , Baofeng Lin 1
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.carbpol.2020.115848 Guohuan Huang 1 , Yanming Li 2 , Zhimei Qin 1 , Qun Liang 1 , Chuanhui Xu 1 , Baofeng Lin 1
Affiliation
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This study posed a novel strategy of interweaving carboxymethyl chitosan (CMCS) and HKUST-1 to build eco-friendly, recyclable, long-acting and intelligent antibacterial agent carrier of HKUST-1@CMCS. Combined characterizations revealed that the structure of HKUST-1@CMCS was destroyed step by step through different intensity of the stimulation of phosphate, thereby realizing intelligent release of antibacterial agent. The results showed that dimethyl fumarate-loaded HKUST-1@CMCS was much intelligent and long-acting (384 h, 0.04 M PBS) release performance than pure dimethyl fumarate, thus its inhibition zone diameters with and without stimulation of phosphate on S. aureus were 17.4 ± 0.1, 10.2 ± 0.7 mm at 7 d, respectively, while that of pure dimethyl fumarate had lost antibacterial activity at 2 d. With superior and long-acting antimicrobial activity, dimethyl fumarate-loaded HKUST-1@CMCS could effectively prolong the shelf life of strawberries as food packaging. Furthermore, HKUST-1@CMCS could easily regenerate, and regenerated HKSUT-1@CMCS still maintained intelligent response property at one cycle.
中文翻译：
羧甲基壳聚糖与MOF的杂交，以构建可回收，长效和智能的抗菌剂载体。
这项研究提出了一种将羧甲基壳聚糖（CMCS）和HKUST-1交织在一起的新策略，以构建环保，可回收，长效和智能的HKUST-1 @ CMCS抗菌剂载体。综合特征表明，HKUST-1 @ CMCS的结构通过不同程度的磷酸盐刺激被逐步破坏，从而实现了抗菌剂的智能释放。结果表明，富马酸二甲酯负载的HKUST-1 @ CMCS比纯富马酸二甲酯具有更高的智能性和长效（384 h，0.04 M PBS）释放性能，因此在有和无磷刺激下对金黄色葡萄球菌的抑制带直径均较大。分别在7 d时为17.4±0.1 mm，10.2±0.7 mm，而纯富马酸二甲酯在2 d时失去了抗菌活性。富马酸二甲酯负载的HKUST-1 @ CMCS具有优异的长效抗菌活性，可有效延长草莓作为食品包装的货架期。此外，HKUST-1 @ CMCS可以轻松地再生，并且再生的HKSUT-1 @ CMCS仍保持一个周期的智能响应特性。
更新日期：2020-01-09
中文翻译：
羧甲基壳聚糖与MOF的杂交，以构建可回收，长效和智能的抗菌剂载体。
这项研究提出了一种将羧甲基壳聚糖（CMCS）和HKUST-1交织在一起的新策略，以构建环保，可回收，长效和智能的HKUST-1 @ CMCS抗菌剂载体。综合特征表明，HKUST-1 @ CMCS的结构通过不同程度的磷酸盐刺激被逐步破坏，从而实现了抗菌剂的智能释放。结果表明，富马酸二甲酯负载的HKUST-1 @ CMCS比纯富马酸二甲酯具有更高的智能性和长效（384 h，0.04 M PBS）释放性能，因此在有和无磷刺激下对金黄色葡萄球菌的抑制带直径均较大。分别在7 d时为17.4±0.1 mm，10.2±0.7 mm，而纯富马酸二甲酯在2 d时失去了抗菌活性。富马酸二甲酯负载的HKUST-1 @ CMCS具有优异的长效抗菌活性，可有效延长草莓作为食品包装的货架期。此外，HKUST-1 @ CMCS可以轻松地再生，并且再生的HKSUT-1 @ CMCS仍保持一个周期的智能响应特性。
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