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Hybridization of carboxymethyl chitosan with MOFs to construct recyclable, long-acting and intelligent antibacterial agent carrier
Carbohydrate Polymers ( IF 6.044 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.carbpol.2020.115848
Guohuan Huang; Yanming Li; Zhimei Qin; Qun Liang; Chuanhui Xu; Baofeng Lin

This study posed a novel strategy of interweaving carboxymethyl chitosan (CMCS) and HKUST-1 to build eco-friendly, recyclable, long-acting and intelligent antibacterial agent carrier of [email protected] Combined characterizations revealed that the structure of [email protected] was destroyed step by step through different intensity of the stimulation of phosphate, thereby realizing intelligent release of antibacterial agent. The results showed that dimethyl fumarate-loaded [email protected] was much intelligent and long-acting (384 h, 0.04 M PBS) release performance than pure dimethyl fumarate, thus its inhibition zone diameters with and without stimulation of phosphate on S. aureus were 17.4 ± 0.1, 10.2 ± 0.7 mm at 7 d, respectively, while that of pure dimethyl fumarate had lost antibacterial activity at 2 d. With superior and long-acting antimicrobial activity, dimethyl fumarate-loaded [email protected] could effectively prolong the shelf life of strawberries as food packaging. Furthermore, [email protected] could easily regenerate, and regenerated [email protected] still maintained intelligent response property at one cycle.
更新日期:2020-01-09

 

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