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Effect of vitamin D supplementation on clinical outcome and biochemical profile in South Indian population with vitamin D-deficient chronic urticarial - A randomized double-blind placebo controlled trial.
Clinica Chimica Acta ( IF 3.2 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.cca.2020.01.003
Archana Mony 1 , Laxmisha Chandrashekar 2 , Medha Rajappa 1 , Malathi Munisamy 2 , Jaya Prakash Sahoo 3 , Sandhiya Selvarajan 4
Affiliation  

BACKGROUND Chronic urticaria (CU) is a debilitating inflammatory skin disease. Prior studies have shown reduced concentrations of vitamin D in CU and there are limited reports of potential beneficial role for vitamin D supplementation in the treatment of subjects with CU. We assessed the effect of vitamin D supplementation in vitamin D deficient CU patients on the clinical outcome and inflammatory markers in South Indian patients with CU. METHODS This randomized controlled trial involved 120 vitamin-D deficient CU patients. Urticaria activity score (UAS7) and autologous plasma skin test (APST) status was assessed in all cases. CU patients were supplemented with vitamin D with a dose of 60,000 IU fortnightly for a period of 12 weeks and those in the placebo arm received matched placebo. Five milliliters of blood was drawn from all study subjects at baseline and after 12 weeks for assessing inflammatory markers. RESULTS We observed a significant reduction in UAS7 scores after 12 weeks in the vitamin D treated group in comparison to that of placebo. We also noted a significant reduction of the inflammatory cytokines in the vitamin D treated group. CONCLUSION Supplementation with vitamin D among patients with vitamin D deficient CU significantly decreases disease severity which is probably mediated through reduction of systemic inflammation.

中文翻译:

补充维生素D对缺乏维生素D的慢性荨麻疹的南印度人群的临床结局和生化特征的影响-一项随机双盲安慰剂对照试验。

背景技术慢性荨麻疹(CU)是一种使人衰弱的炎性皮肤病。先前的研究表明,CU中维生素D的浓度降低,并且补充维生素D在治疗CU受试者中潜在有益作用的报道有限。我们评估了维生素D缺乏型CU患者补充维生素D对南印度CU患者的临床结局和炎症指标的影响。方法该随机对照试验涉及120例维生素D缺乏症的CU患者。在所有情况下均评估了荨麻疹活性评分(UAS7)和自体血浆皮肤测试(APST)状态。CU患者每两周补充维生素D一次,剂量为60,000 IU,为期12周,安慰剂组的患者接受匹配的安慰剂。在基线时和12周后从所有研究对象中抽取5毫升血液用于评估炎症标志物。结果我们观察到,与安慰剂相比,维生素D治疗组12周后UAS7评分显着降低。我们还注意到维生素D治疗组的炎症细胞因子显着降低。结论维生素D缺乏型CU患者补充维生素D可以显着降低疾病的严重程度,这可能是通过减少全身炎症引起的。我们还注意到维生素D治疗组的炎症细胞因子显着降低。结论维生素D缺乏型CU患者补充维生素D可以显着降低疾病的严重程度,这可能是通过减少全身炎症引起的。我们还注意到维生素D治疗组的炎症细胞因子显着降低。结论维生素D缺乏型CU患者补充维生素D可以显着降低疾病的严重程度,这可能是通过减少全身炎症引起的。
更新日期:2020-01-09
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