Abstract Conducting polymer-noble metal nanocomposites have attracted considerable interest as electrochemical sensors because they provide better sensing responses to different analytes. We report the synthesis of rod like polypyrrole (PPY)-Ag nanocomposite using sodium cholate as soft-template for sensing nanomolar concentration of dopamine (DA). The nanocomposites were characterized by employing FT-IR, XRD, scanning and transmission electron microscopic analysis. Electrochemical impedance spectroscopy and cyclic voltammetry experiments were performed for electrochemical characterization of the PPY-Ag nanocomposite deposited on glassy carbon electrode (GCE). Electrochemical detection of DA using this nanocomposite deposited on GCE was done following linear sweep voltammetry. The PPY-Ag nanocomposite deposited electrode showed improved sensitivity value of 8.22 mAμM−1 for DA and a detection limit of 0.00005 μM. Biocompatibility assay of the developed PPY-Ag nanocomposites have exhibited less toxicity to mouse fibroblast cell even in comparison to that of PPY without silver. Antimicrobial property of the PPY-Ag nanocomposites towards E.coli and S. Aureus have also been observed.

中文翻译：

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胆酸钠定制聚吡咯-银纳米复合材料对多巴胺的选择性传感

摘要 导电聚合物-贵金属纳米复合材料作为电化学传感器引起了相当大的兴趣，因为它们对不同的分析物提供更好的传感响应。我们报告了使用胆酸钠作为软模板来检测多巴胺 (DA) 纳摩尔浓度的棒状聚吡咯 (PPY)-Ag 纳米复合材料的合成。采用FT-IR、XRD、扫描和透射电子显微分析对纳米复合材料进行了表征。进行电化学阻抗谱和循环伏安法实验以对沉积在玻璃碳电极 (GCE) 上的 PPY-Ag 纳米复合材料进行电化学表征。使用沉积在 GCE 上的这种纳米复合材料对 DA 进行电化学检测是在线性扫描伏安法之后进行的。PPY-Ag 纳米复合沉积电极对 DA 的灵敏度提高了 8.22 mAμM-1，检测限为 0.00005 μM。与不含银的 PPY 相比，开发的 PPY-Ag 纳米复合材料的生物相容性测定对小鼠成纤维细胞的毒性更低。PPY-Ag 纳米复合材料对大肠杆菌和金黄色葡萄球菌的抗菌性能也已被观察到。