Bufadienolides are a type of natural cardiac steroids and originally isolated from the Traditional Chinese Medicine Chan'Su, they have been used for the treatment of heart disease in traditional remedies as well as in modern medicinal therapy with potent anti-tumor activities. Due to their unique molecular structures with unsaturated six-membered lactones attached to the steroid core, bufadienolides have received great attention in the synthetic organic community. This review presents total synthetic efforts to some representative bufadienolides, chemical modification of bufadienolides will also be given to discuss their structure-activity relationship in anti-tumor.

中文翻译：

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布法二烯内酯的全合成，化学修饰和构效关系。

丁二烯内酯是一种天然的心脏甾体，最初从中药Chan'Su中分离出来，已被用于传统药物以及具有有效抗肿瘤活性的现代药物疗法中的心脏病治疗。由于其独特的分子结构，其不饱和六元内酯连接在甾体核心上，因此，丁二烯内酯在合成有机社区受到了极大关注。这篇综述提出了一些代表性的丁二烯内酯的总合成努力，还将对丁二烯内酯进行化学修饰以讨论它们在抗肿瘤中的构效关系。