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Asymmetric meso-CF3-dipyrromethanes with amino- and heterocyclic functions from trifluoro(pyrrolyl)ethanols and pyrroles
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.jfluchem.2020.109455
Denis N. Tomilin , Lyubov N. Sobenina , Olga V. Petrova , Elena F. Sagitova , Arsalan B. Budaev , Igor A. Ushakov , Andrey V. Ivanov , Boris A. Trofimov

Asymmetric meso-CF3-dipyrromethanes with amino- and nitrogen heterocyclic functions, a new family of the BODIPY dye precursors, have been synthesized in 70-90% yield by condensation of trifluoro(pyrrolyl)ethanols with pyrroles in the presence of AlCl3. This catalyst, for the first time, was shown to be more efficient than commonly used P2O5, which was entirely inactive in the condensation of pyrroles having basic substituents (amino group and pyrazole moiety).



中文翻译:

三氟(吡咯基)乙醇和吡咯具有氨基和杂环功能的不对称内消旋-CF 3-二吡咯甲烷

具有氨基和氮杂环功能的不对称内消旋-CF 3-二吡咯甲烷,是BODIPY染料前体的一个新家族,通过在AlCl 3存在下三氟(吡咯基)乙醇与吡咯的缩合反应以70-90%的产率合成。该催化剂首次显示出比通常使用的P 2 O 5更有效,该催化剂在具有碱性取代基(氨基和吡唑部分)的吡咯的缩合中完全不活泼。

更新日期:2020-01-09
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