Gold-core mesoporous silica shell (AuMSS) nanorods unique physicochemical properties makes them versatile and promising nanomedicines for cancer photothermal therapy. Nevertheless, these nanomaterials present a reduced half-life in the blood and poor specificity towards the tumor tissue. Herein, d-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) and Hyaluronic Acid (HA) were combined for the first time to improve the AuMSS nanorods biological performance. The obtained results revealed that AuMSS surface functionalization induced the surface charge neutralization, from -28 ± 10 mV to -3 ± 5 mV and -10 ± 4 mV for AuMSS-TPGS-HA (1:1) and (4:1) formulations, without impacting on nanomaterials' photothermal capacity. Moreover, the AuMSS functionalization improved the nanomaterials hemocompatibility and selectivity towards the cancer cells, particularly in the AuMSS-TPGS-HA (4:1) formulation. Furthermore, both formulations were able to mediate an on-demand photothermal effect, that induced the HeLa cancer cells death, confirming its potential for being applied as targeted multifunctional theragnostic nanomedicines.

中文翻译：

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透明质酸和维生素E聚乙二醇琥珀酸酯功能化的金芯硅胶壳纳米棒，用于针对癌症的光热疗法。

金核中孔二氧化硅壳（AuMSS）纳米棒独特的理化性质使其成为用于癌症光热疗法的多功能且有前途的纳米药物。然而，这些纳米材料呈现出降低的血液半衰期和对肿瘤组织的特异性差。本文中，首次将d-α-生育酚聚乙二醇1000琥珀酸酯（TPGS）和透明质酸（HA）结合使用，以改善AuMSS纳米棒的生物学性能。获得的结果表明，AuMSS-TPGS-HA（1：1）和（4：1）制剂的AuMSS表面官能化诱导了表面电荷中和，从-28±10 mV到-3±5 mV和-10±4 mV。 ，而不会影响纳米材料的光热容量。此外，AuMSS功能化改善了纳米材料对癌细胞的血液相容性和选择性，特别是在AuMSS-TPGS-HA（4：1）配方中。此外，两种制剂均能够介导按需诱导的光热效应，从而诱导HeLa癌细胞死亡，从而证实了其潜在的用途，可作为靶向多功能Theragnostic纳米药物。