The syndrome of heart failure (HF) with preserved ejection fraction (HFpEF) is now recognized to account for up to half of HF cases and is the dominant form of HF in older adults, especially women. Multiple factors conspire in this predilection of HFpEF for older women. This review will discuss the epidemiology, pathophysiology, prognosis, and treatment of HFpEF with emphasis on the similarities and differences in cardiovascular aging changes, and the differential impact of comorbidities in women versus men. Responses to pharmacologic and lifestyle interventions are also reviewed. We conclude by suggesting future directions for both prevention and treatment of this common and highly morbid cardiovascular disorder.

中文翻译：

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保留射血分数的心力衰竭：男女之间的异同。

如今，公认的射血分数（HFpEF）保持不变的心力衰竭综合征（HF）占HF病例的一半，并且是老年人，尤其是女性中HF的主要形式。HFpEF偏爱老年妇女的因素众多。这篇综述将讨论HFpEF的流行病学，病理生理学，预后和治疗，重点是心血管衰老变化的相似性和差异性，以及男女共病的差异性影响。还审查了对药物和生活方式干预措施的反应。最后，我们提出了预防和治疗这种常见和高度病态的心血管疾病的未来方向。