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Multifunctional gap-enhanced Raman tags for preoperative and intraoperative cancer imaging.
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.actbio.2020.01.006 Bowen Shi 1 , Benyan Zhang 2 , Yuqing Zhang 3 , Yuqing Gu 4 , Chao Zheng 4 , Jing Yan 5 , Weibo Chen 6 , Fuhua Yan 1 , Jian Ye 7 , Huan Zhang 1
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.actbio.2020.01.006 Bowen Shi 1 , Benyan Zhang 2 , Yuqing Zhang 3 , Yuqing Gu 4 , Chao Zheng 4 , Jing Yan 5 , Weibo Chen 6 , Fuhua Yan 1 , Jian Ye 7 , Huan Zhang 1
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Multi-modality imaging agents are desirable for tumor diagnosis because they can provide more alternative and reliable information for accurate detection and therapy of diseases than single imaging technique. However, most reported conventional imaging agents have not been found to successfully overcome the disadvantages of traditional diagnoses such as sensitivity, spatial resolution, short half-decay time and complexity. Therefore, exploring a multifunctional nanocomposite with the combination of their individual modality characteristics has great impact on preoperative imaging and intraoperative diagnosis of cancer. In our study, mesoporous silica gadolinium-loaded gap-enhanced Raman tags (Gd-GERTs) specifically for preoperative and intraoperative imaging are designed and their imaging capability and biosafety are examined. They exhibit strong attenuation property for computed X-ray tomography (CT) imaging, high T1 relaxivity for magnetic resonance (MR) imaging capability and surface-enhanced Raman spectroscopy (SERS) signal with good dispersity and stability, which presents CT/MR/SERS multi-mode imaging performance of the tumor of mice within a given time. Furthermore, in vivo biodistribution and long-term toxicity studies reveal that the Gd-GERTs have good biocompatibility and bio-safety. Therefore, Gd-GERTs are of great potential as a multifunctional nanoplatform for accurate preoperative CT/MRI diagnosis and intraoperative Raman imaging-guide resection of cancers. STATEMENT OF SIGNIFICANCE: Recent advances in molecular imaging technology have provided a myriad of opportunities to prepare various nanomaterials for accurate diagnosis and response evaluation of cancer via different imaging modalities. However, single bioimaging modality is still challenging to overcome the issues such as sensitivity, spatial resolution, imaging speed and complexity for clinicians. In this work, we designed a kind of unique multifunctional nanoprobes with computed X-ray tomography/magnetic resonance/surface-enhanced Raman spectroscopy (CT/MR/SERS) triple-modal imaging capabilities. Multifunctional nanotags offer the capabilities of preoperative noninvasive CT/MR imaging for identification of tumors as well as intraoperative real-time SERS imaging for guidance of complete resection of tumors. These multifunctional nanoprobes show critical clinical significance on the improvement of tumor diagnosis and therapy.
中文翻译：
多功能间隙增强拉曼标签用于术前和术中癌症成像。
多模态成像剂是肿瘤诊断所需要的，因为与单一成像技术相比，它们可以为疾病的准确检测和治疗提供更多替代和可靠的信息。然而，尚未发现大多数报道的常规显像剂能成功克服传统诊断的缺点，例如灵敏度，空间分辨率，短半衰期和复杂性。因此，探索结合其各自的形态特征的多功能纳米复合材料对癌的术前成像和术中诊断具有重大影响。在我们的研究中，设计了专门用于术前和术中成像的介孔二氧化硅负载的间隙增强拉曼标签（Gd-GERTs），并检查了它们的成像能力和生物安全性。它们对计算机X射线断层扫描（CT）成像表现出强大的衰减特性，对磁共振（MR）成像能力具有很高的T1弛豫性，并且具有良好的分散性和稳定性，并具有增强的表面增强拉曼光谱（SERS）信号，这表明CT / MR / SERS给定时间内小鼠肿瘤的多模式成像性能。此外，体内生物分布和长期毒性研究表明，Gd-GERT具有良好的生物相容性和生物安全性。因此，Gd-GERTs作为多功能纳米平台具有巨大的潜力，可用于准确的术前CT / MRI诊断和术中拉曼成像指导切除术。重要性声明：分子成像技术的最新进展提供了无数机会来制备各种纳米材料，以通过不同的成像方式对癌症进行准确的诊断和反应评估。然而，单一的生物成像方式仍然难以克服诸如临床医生的敏感性，空间分辨率，成像速度和复杂性等问题。在这项工作中，我们设计了一种独特的多功能纳米探针，具有计算机X射线断层扫描/磁共振/表面增强拉曼光谱（CT / MR / SERS）三重模态成像功能。多功能纳米标签可提供术前无创CT / MR成像以识别肿瘤以及术中实时SERS成像以指导肿瘤完全切除的功能。
更新日期：2020-01-09
中文翻译：
多功能间隙增强拉曼标签用于术前和术中癌症成像。
多模态成像剂是肿瘤诊断所需要的，因为与单一成像技术相比，它们可以为疾病的准确检测和治疗提供更多替代和可靠的信息。然而，尚未发现大多数报道的常规显像剂能成功克服传统诊断的缺点，例如灵敏度，空间分辨率，短半衰期和复杂性。因此，探索结合其各自的形态特征的多功能纳米复合材料对癌的术前成像和术中诊断具有重大影响。在我们的研究中，设计了专门用于术前和术中成像的介孔二氧化硅负载的间隙增强拉曼标签（Gd-GERTs），并检查了它们的成像能力和生物安全性。它们对计算机X射线断层扫描（CT）成像表现出强大的衰减特性，对磁共振（MR）成像能力具有很高的T1弛豫性，并且具有良好的分散性和稳定性，并具有增强的表面增强拉曼光谱（SERS）信号，这表明CT / MR / SERS给定时间内小鼠肿瘤的多模式成像性能。此外，体内生物分布和长期毒性研究表明，Gd-GERT具有良好的生物相容性和生物安全性。因此，Gd-GERTs作为多功能纳米平台具有巨大的潜力，可用于准确的术前CT / MRI诊断和术中拉曼成像指导切除术。重要性声明：分子成像技术的最新进展提供了无数机会来制备各种纳米材料，以通过不同的成像方式对癌症进行准确的诊断和反应评估。然而，单一的生物成像方式仍然难以克服诸如临床医生的敏感性，空间分辨率，成像速度和复杂性等问题。在这项工作中，我们设计了一种独特的多功能纳米探针，具有计算机X射线断层扫描/磁共振/表面增强拉曼光谱（CT / MR / SERS）三重模态成像功能。多功能纳米标签可提供术前无创CT / MR成像以识别肿瘤以及术中实时SERS成像以指导肿瘤完全切除的功能。
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