Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species. Plasma XOR activity is a metabolic biomarker associated with obesity, hyperuricemia, liver dysfunction and insulin resistance. However, it has recently been reported that XOR activity in fat tissue is low in humans, unlike in rodents, and that hypoxanthine is secreted from human fat tissue.

中文翻译：

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一般人群肥胖对次黄嘌呤和黄嘌呤的差异调节。

尿酸是通过使用催化酶黄嘌呤氧化还原酶 (XOR) 氧化次黄嘌呤和黄嘌呤来合成的，XOR 可以是活性氧的来源。血浆异或活性是与肥胖、高尿酸血症、肝功能障碍和胰岛素抵抗相关的代谢生物标志物。然而，最近有报道称，与啮齿动物不同，人类脂肪组织中的 XOR 活性较低，并且次黄嘌呤是从人体脂肪组织中分泌的。