In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma parenchymal brain metastases was published (Eroglu et al., Pigment Cell & Melanoma Research , 2019, 32, 458). Here, we will describe the current state of basic, translational, clinical research, and therapeutic management, for melanoma patients with leptomeningeal disease. We also outline key challenges and barriers to be overcome to make progress in this deadly disease.

中文翻译：

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黑色素瘤患者的软脑膜疾病：治疗、挑战和未来方向的更新。


2018 年 2 月，黑色素瘤研究基金会和莫菲特癌症中心在佛罗里达州坦帕主办了第二届黑色素瘤中枢神经系统转移峰会。会议包括来自多个学术中心和学科的研究人员。黑色素瘤实质脑转移的进展和挑战的共识总结已发表（Eroglu et al., Pigment Cell & Melanoma Research , 2019, 32, 458）。在这里，我们将描述患有软脑膜疾病的黑色素瘤患者的基础、转化、临床研究和治疗管理的现状。我们还概述了在这种致命疾病方面取得进展需要克服的关键挑战和障碍。