In the first published efficacy study of cenobamate for treatment-resistant focal seizures, high doses produced high seizure-free rates, suggesting cenobamate can outperform existing options. A risk of serious rash and low tolerability at higher doses means further safety studies and clinical experience are needed to determine its clinical value.

中文翻译：

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Cenobamate用于局部发作-改变游戏规则？

在第一个发表的cenobamate治疗难治性局灶性癫痫疗效研究中，高剂量产生高无癫痫发作率，这表明cenobamate的表现优于现有选择。高剂量有发生严重皮疹和低耐受性的风险，这意味着需要进一步的安全性研究和临床经验，以确定其临床价值。