Synthesis of Riboflavin‐Based Macromolecules through Low ppm ATRP in Aqueous Media,Macromolecular Chemistry and Physics

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Synthesis of Riboflavin‐Based Macromolecules through Low ppm ATRP in Aqueous Media
Macromolecular Chemistry and Physics ( IF 2.5 ) Pub Date : 2020-01-09 , DOI: 10.1002/macp.201900496
Izabela Zaborniak _{1,

2} , Paweł Chmielarz _{1,

2} , Krzysztof Matyjaszewski ₂

Affiliation

A vitamin‐B₂‐based macroinitiator is prepared by esterification of riboflavin with 2‐bromoisobutyryl bromide. Following the “core first” methodology, “phoenix”‐shape (co)polymers with a polar riboflavin core and either a hydrophobic (poly(n‐butyl acrylate) or poly(methyl methacrylate)) or hydrophilic (poly(N‐isopropylacrylamide)‐block‐poly(oligo(ethylene glycol) acrylate) or poly(N‐isopropylacrylamide)‐block‐poly(2‐hydroxyethyl acrylate)) tails are synthesized via low ppm atom transfer radical polymerization procedures. Polymers have predetermined molecular weights and a low dispersity (Ð < 1.2). ¹H NMR analysis confirms the successful formation of targeted (co)polymers with the preserved riboflavin functionality.

中文翻译：

水性介质中低ppm ATRP合成基于核黄素的大分子

一种基于维生素B ₂的大分子引发剂是通过核黄素与2-溴异丁酰溴的酯化反应制备的。遵循“核心优先”方法，具有极性核黄素核心，疏水性（聚（丙烯酸正丁酯）或聚甲基丙烯酸甲酯）或亲水性（聚（N-异丙基丙烯酰胺））的“凤凰”形（共）聚合物-块-聚（低聚（乙二醇）丙烯酸酯）或聚（ñ -isopropylacrylamide） -嵌段-聚（2-羟乙基丙烯酸酯））尾经由低ppm原子转移自由基聚合方法合成。聚合物具有预定的分子量和较低的分散度（Ð <1.2）。^1个1 H NMR分析证实成功形成具有保留的核黄素官能度的目标（共）聚合物。

更新日期：2020-01-09

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