In this open-label, single-arm phase 2 trial, Edeline and colleagues evaluated concomitant first-line chemotherapy with cisplatin and gemcitabine with selective internal radiotherapy for treatment of unresectable intrahepatic cholangiocarcinoma (ICC). A total of 41 patients were enrolled. The combination chemotherapy and radiotherapy had antitumor activity in unresectable ICC, and a significant proportion of patients were downstaged to surgical intervention. Scott and Shroff provide an Editorial.

Editorial

In this single-arm phase 2 clinical trial by Cercek and colleagues, 38 patients with unresectable intrahepatic cholangiocarcinoma (ICC) were treated with hepatic arterial infusion of floxuridine in combination with systemic gemcitabine and oxaliplatin. Hepatic arterial infusion plus systemic chemotherapy appears to be highly active and tolerable in patients with unresectable ICC. Scott and Shroff provide an Editorial.

在这项开放性单臂2期试验中，Edeline及其同事评估了顺铂和吉西他滨与选择性内放疗同时进行的一线化疗联合治疗不可切除的肝内胆管癌（ICC）的可能性。共有41位患者入选。化学疗法和放射疗法的结合在不可切除的ICC中具有抗肿瘤活性，并且很大一部分患者已下调至外科手术的治疗。斯科特（Scott）和斯罗夫（Shroff）提供社论。

社论

在Cercek及其同事进行的单臂2期临床试验中，对38例不可切除的肝内胆管癌（ICC）患者进行了肝动脉灌注氟尿嘧啶与全身吉西他滨和奥沙利铂联合治疗。不可切除ICC患者肝动脉灌注加全身化疗似乎是高度活跃和可耐受的。斯科特（Scott）和斯罗夫（Shroff）提供社论。