Phomeroids A and B: two novel cytotoxic meroterpenoids from the deep-sea-derived fungus Phomopsis tersa FS441,Organic Chemistry Frontiers

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Phomeroids A and B: two novel cytotoxic meroterpenoids from the deep-sea-derived fungus Phomopsis tersa FS441
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020/01/09 , DOI: 10.1039/c9qo01365b
Shanchong Chen _{1,

2,

3,

4,

5} , Zhaoming Liu _{1,

2,

3,

4,

5} , Haibo Tan _{6,

7,

8,

9,

10} , Yuchan Chen _{1,

2,

3,

4,

5} , Saini Li _{1,

2,

3,

4,

5} , Haohua Li _{1,

2,

3,

4,

5} , Shuang Zhu _{11,

12,

13,

14} , Hongxin Liu _{1,

2,

3,

4,

5} , Weimin Zhang _{1,

2,

3,

4,

5}

Affiliation

State Key Laboratory of Applied Microbiology Southern China
Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application
Guangdong Open Laboratory of Applied Microbiology
Guangdong Institute of Microbiology
Guangdong Academy of Sciences
Program for Natural Products Chemical Biology
Key Laboratory of Plant Resources Conservation and Sustainable Utilization
Guangdong Provincial Key Laboratory of Applied Botany
South China Botanical Garden
Chinese Academy of Sciences
School of Biosciences and Biopharmaceutics
Guangdong Pharmaceutical University
Guangzhou 510006
China

Phomeroids A (1) and B (2), two novel meroterpenoids representing two types of skeletons, together with one known homologous analogue (3) were isolated from the deep-sea-derived fungus Phomopsis tersa FS441. Phomeroid A is the first example of tropolonic sesquiterpenes consisting of a highly fused 6/6/11/6/5/5 ring system, while phomeroid B is the first example of meroterpenoids featuring an unusual 7/6/11/6-5 spiral core skeleton. All of them showed considerable cytotoxicity against the tested cell lines, and their biosynthetic pathways were also discussed.

中文翻译：

Phomeroids A和B：来自深海真菌Phomopsis tersa FS441的两种新型细胞毒性类萜

从深海来源的真菌Phomopsis tersa FS441分离出了拟南芥A（1）和B（2），代表两种类型骨架的两种新型甲肾上腺素，以及一种已知的同源类似物（3）。Phomeroid A是由高度融合的6/6/11/6/5/5环系统组成的对流线倍半萜的第一个例子，而phomeroid B是具有不寻常的7/6/11 / 6-5螺旋形的美萜类的第一个例子核心骨架。它们都对被测细胞系表现出相当大的细胞毒性，并且还讨论了它们的生物合成途径。

更新日期：2020-02-13

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