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Fluorescent glycoconjugates and their applications.
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-01-09 , DOI: 10.1039/c8cs00118a Baptiste Thomas 1 , Kai-Cheng Yan 2 , Xi-Le Hu 2 , Marion Donnier-Maréchal 1 , Guo-Rong Chen 2 , Xiao-Peng He 2 , Sébastien Vidal 1
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-01-09 , DOI: 10.1039/c8cs00118a Baptiste Thomas 1 , Kai-Cheng Yan 2 , Xi-Le Hu 2 , Marion Donnier-Maréchal 1 , Guo-Rong Chen 2 , Xiao-Peng He 2 , Sébastien Vidal 1
Affiliation
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Glycoconjugates and their applications as lectin ligands in biology have been thoroughly investigated in the past decades. Meanwhile, the intrinsic properties of such multivalent molecules were limited essentially to their ability to bind to their receptors with high selectivity and/or avidity. The present review will focus on multivalent glycoconjugates displaying an additional capability such as fluorescence properties not only for applications toward imaging of cancer cells and detection of proteins or pathogens but also for drug delivery systems toward targeted cancer therapy. This review is a collection of research articles discussed in the context of the structural features of fluorescent glycoconjugates organized according to their fluorescent core scaffold and with their representative applications.
中文翻译：
荧光糖缀合物及其应用。
糖缀合物及其在生物学上作为凝集素配体的应用在过去的几十年中已得到深入研究。同时，这种多价分子的内在性质基本上受限于它们以高选择性和/或亲和力结合其受体的能力。本综述将集中在显示附加功能的多价糖缀合物上，例如荧光性质，不仅用于癌细胞成像和蛋白质或病原体检测的应用，而且还用于靶向癌症治疗的药物递送系统。这篇综述是在根据荧光糖缀合物的结构特征和其代表性应用组织的荧光糖缀合物的结构特征的背景下讨论的研究文章的集合。
更新日期：2020-02-13
中文翻译：
荧光糖缀合物及其应用。
糖缀合物及其在生物学上作为凝集素配体的应用在过去的几十年中已得到深入研究。同时，这种多价分子的内在性质基本上受限于它们以高选择性和/或亲和力结合其受体的能力。本综述将集中在显示附加功能的多价糖缀合物上，例如荧光性质，不仅用于癌细胞成像和蛋白质或病原体检测的应用，而且还用于靶向癌症治疗的药物递送系统。这篇综述是在根据荧光糖缀合物的结构特征和其代表性应用组织的荧光糖缀合物的结构特征的背景下讨论的研究文章的集合。
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