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Therapeutic and Preventive Effect of Voluntary Running Wheel Exercise on Social Defeat Stress (SDS)-induced Depressive-like Behavior and Chronic Pain in Mice.
Neuroscience ( IF 2.9 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.neuroscience.2019.12.037
M Pagliusi 1 , I J M Bonet 2 , A F Brandão 1 , S F Magalhães 1 , C H Tambeli 1 , C A Parada 1 , C R Sartori 1
Affiliation  

Major depressive disorders (MDD) and chronic pain (CP) affect significant portion of the world's population and have high comorbidity rate. Social defeat stress (SDS) model was standardized in mice and can trigger depressive-like behavior and chronic pain. Based especially on clinical trials showing an effective preventive and therapeutic effect of physical exercise on CP and symptoms associated with MDD, this study aimed to investigate if the voluntary running wheel exercise can exert these effects in mice submitted to the 10-day SDS protocol, using fluoxetine as positive control. For this, we ran two set of experiments: in the first set mice started performing voluntary running wheel exercise after submitted to SDS and, in the second set, mice performed voluntary running wheel exercise before and during SDS. Mechanical and chemical hyperalgesia was analyzed through electronic von Frey and capsaicin test, respectively. Depressive-like behavior was assessed through social interaction test. Our results showed that the voluntary running wheel exercise was more effective than fluoxetine reversing the SDS-induced persistent hyperalgesia and both, fluoxetine and voluntary running wheel exercise, was effective reversing SDS-induced social avoidance. Also, voluntary running wheel exercise is an effective tool preventing both hyperalgesia and social avoidance induced by SDS. To the best of our knowledge, this was the first study using physical exercise as a therapeutic and preventive tool for chronic pain and depressive-like behavior simultaneously induced by social stress.

中文翻译:

自愿性转轮运动对社交失败压力(SDS)诱发的小鼠抑郁样行为和慢性疼痛的治疗和预防作用。

严重的抑郁症(MDD)和慢性疼痛(CP)影响世界上很大一部分人口,合并症发生率很高。社交挫败压力(SDS)模型在小鼠中得到了标准化,可以触发类似抑郁的行为和慢性疼痛。特别是根据临床研究表明体育锻炼对CP和与MDD相关的症状具有有效的预防和治疗作用,本研究旨在研究自愿性轮转运动是否可以在提交10天SDS方案的小鼠中发挥这些作用,方法是:氟西汀作为阳性对照。为此,我们进行了两组实验:第一组小鼠在接受SDS后开始进行自愿性的跑轮运动;第二组小鼠在SDS之前和之中进行了自愿性的跑轮运动。机械性和化学性痛觉过敏分别通过电子von Frey和辣椒素测试进行分析。通过社交互动测试评估了抑郁症样的行为。我们的结果表明,自愿性轮转运动比氟西汀逆转SDS引起的持续性痛觉过敏更有效,氟西汀和自愿性轮转运动两者均能有效逆转SDS引起的社会回避。此外,自愿性的轮转运动是预防痛觉过敏和SDS引起的社会回避的有效工具。据我们所知,这是第一项使用体育锻炼作为社交压力同时诱发的慢性疼痛和抑郁样行为的治疗和预防工具的研究。通过社交互动测试评估了抑郁症样的行为。我们的结果表明,自愿性轮转运动比氟西汀逆转SDS引起的持续性痛觉过敏更有效,氟西汀和自愿性轮转运动两者均能有效逆转SDS引起的社会回避。此外,自愿性的轮转运动是预防痛觉过敏和SDS引起的社会回避的有效工具。据我们所知,这是第一项使用体育锻炼作为社交压力同时诱发的慢性疼痛和抑郁样行为的治疗和预防工具的研究。通过社交互动测试评估了抑郁症样的行为。我们的结果表明,自愿性轮转运动比氟西汀逆转SDS引起的持续性痛觉过敏更有效,氟西汀和自愿性轮转运动两者均能有效逆转SDS引起的社会回避。此外,自愿性的轮转运动是预防痛觉过敏和SDS引起的社会回避的有效工具。据我们所知,这是第一项使用体育锻炼作为社交压力同时诱发的慢性疼痛和抑郁样行为的治疗和预防工具的研究。我们的结果表明,自愿性轮转运动比氟西汀逆转SDS引起的持续性痛觉过敏更有效,氟西汀和自愿性轮转运动两者均能有效逆转SDS引起的社会回避。此外,自愿性的轮转运动是预防痛觉过敏和SDS引起的社会回避的有效工具。据我们所知,这是第一项使用体育锻炼作为社交压力同时诱发的慢性疼痛和抑郁样行为的治疗和预防工具的研究。我们的结果表明,自愿性轮转运动比氟西汀逆转SDS引起的持续性痛觉过敏更有效,氟西汀和自愿性轮转运动两者均能有效逆转SDS引起的社会回避。此外,自愿性的轮转运动是预防痛觉过敏和SDS引起的社会回避的有效工具。据我们所知,这是第一项使用体育锻炼作为社交压力同时诱发的慢性疼痛和抑郁样行为的治疗和预防工具的研究。
更新日期:2020-01-09
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