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Persisting Antibody Response 9 Years After Bivalent Human Papillomavirus (HPV) Vaccination in a Cohort of Dutch Women: Immune Response and the Relation to Genital HPV Infections.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-05-11 , DOI: 10.1093/infdis/jiaa007
Joske Hoes 1, 2 , Hella Pasmans 1, 3 , Mirjam J Knol 1 , Robine Donken 4, 5 , Naomi van Marm-Wattimena 1 , Rutger M Schepp 1 , Audrey J King 1 , Fiona R M van der Klis 1 , Hester E de Melker 1
Affiliation  

The bivalent human papillomavirus (HPV) vaccine is highly effective and induces robust serological responses. Using a Dutch prospective cohort initiated in 2009, including 744 vaccinated and 294 unvaccinated girls (1993-1994) who provide a vaginal self-swab sample, serum sample, and questionnaire yearly, we report a high, persisting antibody response up to 9 years after vaccination for vaccine types HPV-16 or HPV-18. Antibodies against nonvaccine HPV types 31, 33, 45, 52, and 58 were lower but still significantly higher than in unvaccinated individuals. This was also reflected in the seroprevalence. We compared participant characteristics and antibody levels between vaccinated women with and those without HPV infections 1 year before infection (204 incident and 64 persistent infections), but we observed no consistent difference in type-specific antibody levels. Having a high-risk HPV infection was associated with sexual risk behavior and smoking 1 year before infection. Although high antibody levels are necessary for protection, our study suggests that on the individual level other factors such as HPV exposure or antibody avidity could be important.

中文翻译:

在荷兰妇女队列中的二价人乳头瘤病毒(HPV)疫苗接种后9年持续存在抗体应答:免疫应答及其与生殖器HPV感染的关系。

二价人乳头瘤病毒(HPV)疫苗非常有效,可诱导强大的血清反应。使用2009年发起的荷兰前瞻性队列研究,其中包括744名接种疫苗的女孩和294名未接种疫苗的女孩(1993年至1994年),他们每年提供一次阴道自拭子样本,血清样本和问卷调查,我们报告了在9年后持续的高抗体应答HPV-16或HPV-18疫苗的预防接种。针对非疫苗型HPV 31、33、45、52和58的抗体含量较低,但仍显着高于未疫苗接种的个体。血清阳性率也反映了这一点。我们比较了感染前1年(有204例事件和64例持续感染)的,有和没有HPV感染的疫苗接种妇女之间的参与者特征和抗体水平,但我们观察到类型特异性抗体水平没有一致的差异。HPV高危感染与性危险行为和感染前1年吸烟有关。尽管高水平的抗体对于保护很有必要,但我们的研究表明,就个体而言,其他因素(例如HPV暴露或抗体亲和力)可能很重要。
更新日期:2020-01-09
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