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Personalizing KRAS-Mutant Allele-Specific Therapies.
Cancer Discovery ( IF 29.7 ) Pub Date : 2020-01-01 , DOI: 10.1158/2159-8290.cd-19-1261 Chiara Falcomatà 1, 2 , Günter Schneider 1, 3 , Dieter Saur 1, 2, 3
Cancer Discovery ( IF 29.7 ) Pub Date : 2020-01-01 , DOI: 10.1158/2159-8290.cd-19-1261 Chiara Falcomatà 1, 2 , Günter Schneider 1, 3 , Dieter Saur 1, 2, 3
Affiliation
KRAS G12R mutations occur almost exclusively in pancreatic ductal adenocarcinoma. The results of a study that reveals specific differences in KRAS downstream signaling and metabolic rewiring of pancreatic cancer cells harboring KRAS G12R mutations promise to improve our possibilities to better stratify patients for individualized therapies.See related article by Hobbs et al., p. 104.
中文翻译:
个性化 KRAS 突变等位基因特异性疗法。
KRAS G12R 突变几乎只发生在胰腺导管腺癌中。一项研究结果揭示了携带 KRAS G12R 突变的胰腺癌细胞在 KRAS 下游信号传导和代谢重新布线方面的特定差异,有望提高我们更好地对患者进行个体化治疗分层的可能性。104.
更新日期:2020-04-21
中文翻译:
个性化 KRAS 突变等位基因特异性疗法。
KRAS G12R 突变几乎只发生在胰腺导管腺癌中。一项研究结果揭示了携带 KRAS G12R 突变的胰腺癌细胞在 KRAS 下游信号传导和代谢重新布线方面的特定差异,有望提高我们更好地对患者进行个体化治疗分层的可能性。104.