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Effect of m-trifluoromethyl-diphenyl diselenide on acute and subchronic animal models of inflammatory pain: Behavioral, biochemical and molecular insights.
Chemico-Biological Interactions ( IF 4.7 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.cbi.2020.108941 Paulo Cesar Oliveira Araujo 1 , Marcel Henrique Marcondes Sari 2 , Natália Silva Jardim 3 , Juliano Ten Kathen Jung 3 , César Augusto Brüning 4
Chemico-Biological Interactions ( IF 4.7 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.cbi.2020.108941 Paulo Cesar Oliveira Araujo 1 , Marcel Henrique Marcondes Sari 2 , Natália Silva Jardim 3 , Juliano Ten Kathen Jung 3 , César Augusto Brüning 4
Affiliation
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m-Trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] is an organoselenium molecule that displays multiple pharmacological actions, including the antinociceptive effect. The current study investigated the (m-CF3-PhSe)2 restorative properties in models of acute and chronic inflammatory pain induced by complete Freund's adjuvant (CFA). Male adult Swiss mice received an intraplantar injection of CFA in the hindpaw and 24 h (acute) or 14 days (subchronic) later they were treated with a single or repeated (m-CF3-PhSe)2 schedule via intragastric route, respectively. The mechanical and thermal hypernociceptive behaviors were assessed by von Frey hair and hot plate tests. Samples of injected paw were collected to evaluate the tissue edema and myeloperoxidase (MPO) activity while cerebral contralateral cortex samples were used to determine the inflammatory proteins content (subchronic protocol). The acute (m-CF3-PhSe)2 administration (1 and 10 mg/kg) reduced the hypernociceptive behavior and both paw thickness and MPO activity induced by CFA injection. In the subchronic protocol, the repeated administration with a low effective dosage of (m-CF3-PhSe)2 reduced the mechanical and thermal hypernociception as well as restored the edema and MPO activity in paw samples. In addition, the repeated treatment schedule mitigated the increase in TNF-α, IL-1β and COX-2 content in cerebral contralateral cortex induced by CFA injection. Collectively, these data showed that (m-CF3-PhSe)2 presents anti-inflammatory properties, which could be mediated by an interplay between peripheral and central mechanisms of action, reinforcing the potential biological properties of the compound.
中文翻译：
间三氟甲基二苯二硒化物对炎症性疼痛的急性和亚慢性动物模型的影响：行为，生化和分子方面的见解。
间三氟甲基二苯基二硒化物[（m-CF3-PhSe）2]是一种有机硒分子，具有多种药理作用，包括抗伤害感受作用。本研究调查了完全弗氏佐剂（CFA）诱发的急性和慢性炎症性疼痛模型中的（m-CF3-PhSe）2恢复特性。雄性成年瑞士小鼠在后爪中足底注射CFA，24小时（急性）或14天（亚慢性）后，分别通过胃内途径接受单次或重复（m-CF3-PhSe）2方案治疗。机械和热痛觉过敏行为通过冯·弗雷（von Frey）头发和热板测试进行评估。收集注射的爪子样品以评估组织水肿和髓过氧化物酶（MPO）活性，同时使用大脑对侧皮层样品测定炎症蛋白含量（亚慢性）。急性（m-CF3-PhSe）2给药（1和10 mg / kg）降低了CFA注射引起的痛觉过敏行为以及爪厚度和MPO活性。在亚慢性方案中，以低有效剂量的（m-CF3-PhSe）2重复给药减少了机械和热痛觉过敏，并恢复了足爪样品的水肿和MPO活性。此外，重复的治疗方案减轻了注射CFA所致大脑对侧皮质中TNF-α，IL-1β和COX-2含量的增加。这些数据共同表明（m-CF3-PhSe）2具有抗炎特性，
更新日期：2020-01-09
中文翻译：
间三氟甲基二苯二硒化物对炎症性疼痛的急性和亚慢性动物模型的影响：行为，生化和分子方面的见解。
间三氟甲基二苯基二硒化物[（m-CF3-PhSe）2]是一种有机硒分子，具有多种药理作用，包括抗伤害感受作用。本研究调查了完全弗氏佐剂（CFA）诱发的急性和慢性炎症性疼痛模型中的（m-CF3-PhSe）2恢复特性。雄性成年瑞士小鼠在后爪中足底注射CFA，24小时（急性）或14天（亚慢性）后，分别通过胃内途径接受单次或重复（m-CF3-PhSe）2方案治疗。机械和热痛觉过敏行为通过冯·弗雷（von Frey）头发和热板测试进行评估。收集注射的爪子样品以评估组织水肿和髓过氧化物酶（MPO）活性，同时使用大脑对侧皮层样品测定炎症蛋白含量（亚慢性）。急性（m-CF3-PhSe）2给药（1和10 mg / kg）降低了CFA注射引起的痛觉过敏行为以及爪厚度和MPO活性。在亚慢性方案中，以低有效剂量的（m-CF3-PhSe）2重复给药减少了机械和热痛觉过敏，并恢复了足爪样品的水肿和MPO活性。此外，重复的治疗方案减轻了注射CFA所致大脑对侧皮质中TNF-α，IL-1β和COX-2含量的增加。这些数据共同表明（m-CF3-PhSe）2具有抗炎特性，
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