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Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens.
Journal of Natural Products ( IF 4.257 ) Pub Date : 2020-01-09 , DOI: 10.1021/acs.jnatprod.9b00515
Feng Liu,Jun Ma,Zhaoyu Shi,Qi Zhang,Huimei Wang,Dihua Li,Zhaohui Song,Chunyan Wang,Jin Jin,Jing Xu,Muhetaer Tuerhong,Munira Abudukeremu,Ling Shuai,Dongho Lee,Yuanqiang Guo

A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce apoptosis of A549 cells and impede them at the G0/G1 stage.
更新日期:2020-01-09

 

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