Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens.,Journal of Natural Products

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Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-01-09 , DOI: 10.1021/acs.jnatprod.9b00515
Feng Liu ₁ , Jun Ma ₁ , Zhaoyu Shi ₁ , Qi Zhang ₁ , Huimei Wang ₁ , Dihua Li ₂ , Zhaohui Song ₃ , Chunyan Wang ₄ , Jin Jin ₁ , Jing Xu _{1,

5} , Muhetaer Tuerhong ₆ , Munira Abudukeremu ₆ , Ling Shuai ₁ , Dongho Lee ₇ , Yuanqiang Guo ₁

Affiliation

A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce apoptosis of A549 cells and impede them at the G0/G1 stage.

中文翻译：

从干酪毛的叶子中分离出的Clerodane二萜。

一项旨在获取药理活性物质的植物化学调查已从干酪毛的叶子中分离出九种新的克雷烷双萜类化合物，称为gravospenes AI（1-9）。使用光谱学方法建立结构，其绝对构型由ECD数据分析确认。进行了生物学评估，发现化合物1对人肺癌细胞（A549）和人肝细胞癌细胞（HepG2）均具有细胞毒性。对1的作用机理研究表明，该化合物诱导A549细胞凋亡，并在G0 / G1阶段阻止其凋亡。

更新日期：2020-01-09

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