BACKGROUND Epidemiologic studies show that cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) gene polymorphism modifies diet-obesity relationships. However, the interaction between CARTPT gene polymorphism and diet quality indices have not been investigated yet. The current study was aimed to evaluate the interaction between major dietary indices including Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI)-2015 and CARTPT gene rs2239670 variants among apparently healthy obese Iranians. METHODS This cross-sectional study was carried out by employing 288 apparently healthy obese adults aged 20-50 years with a BMI of 30-40 kg/m2. Diet quality was evaluated by Diet Quality Index-International (DQI-I) and Healthy Eating Index-2015 (HEI-2015) using a 132-items semi-quantitative validated food frequency questionnaire. The CARTPT gene rs2239670 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Blood concentrations of glycemic markers, lipid profile, α-melanocyte stimulating hormone (MSH) and agouti-related peptide (AgRP) were also measured. ANCOVA multivariate interaction model was used to analyze gene-diet interactions. RESULTS The significant interactions were identified between CARTPT gene polymorphism and HEI, affecting BMR (PInteraction = 0.003), serum glucose (PInteraction = 0.009) and high density lipoprotein cholesterol HDL concentrations (PInteraction = 0.03) after adjusting for the effects of sex and age. Also we found gene-diet interaction between CARTPT genotypes and DQI-I in terms of fat mass (FM; PInteraction = 0.02), waist circumference (WC; PInteraction < 0.001), body mass index (BMI; PInteraction < 0.001), basal metabolic rate (BMR, PInteraction < 0.001), serum fasting glucose (PInteraction < 0.01) and AgRP (PInteraction = 0.05) in individuals even after adjusting for potential confounders. CONCLUSION Current study showed the effects of interaction between CARTPT genotype with adherence to HEI and DQI-I scores on obesity-related anthropometric and metabolic risk-factors.

中文翻译：

---

可卡因和安非他明调节的转录前原肽基因 (CARTPT) 多态性与国际饮食质量指数 (DQI-I) 和健康饮食指数 (HEI) 相互作用，影响肥胖个体的下丘脑激素和心脏代谢危险因素。


背景流行病学研究表明，可卡因和安非他明调节的转录前肽（CARTPT）基因多态性改变了饮食与肥胖的关系。然而，CARTPT基因多态性与饮食质量指标之间的相互作用尚未得到研究。目前的研究旨在评估主要饮食指数（包括国际饮食质量指数（DQI-I）和健康饮食指数（HEI）-2015）与明显健康的肥胖伊朗人中 CARTPT 基因 rs2239670 变异之间的相互作用。方法 这项横断面研究的对象是 288 名表面健康的肥胖成年人，年龄为 20-50 岁，BMI 为 30-40 kg/m2。饮食质量通过国际饮食质量指数 (DQI-I) 和 2015 年健康饮食指数 (HEI-2015) 使用 132 项半定量验证食物频率问卷进行评估。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术对CARTPT基因rs2239670多态性进行基因分型。还测量了血糖标志物、血脂、α-黑素细胞刺激激素 (MSH) 和刺鼠相关肽 (AgRP) 的血液浓度。使用ANCOVA多变量相互作用模型来分析基因-饮食相互作用。结果在调整性别和年龄的影响后，CARTPT 基因多态性和 HEI 之间存在显着的相互作用，影响 BMR (PInteraction = 0.003)、血糖 (PInteraction = 0.009) 和高密度脂蛋白胆固醇 HDL 浓度 (PInteraction = 0.03)。我们还发现 CARTPT 基因型和 DQI-I 之间在脂肪量 (FM; PInteraction = 0.02)、腰围 (WC; PInteraction < 0.001)、体重指数 (BMI; PInteraction < 0.001)、基础代谢方面存在基因-饮食相互作用。率（BMR、PInteraction < 0。001)、血清空腹血糖 (PInteraction < 0.01) 和 AgRP (PInteraction = 0.05)，即使在调整了潜在的混杂因素后也是如此。结论 目前的研究表明，CARTPT 基因型与遵守 HEI 和 DQI-I 评分之间的相互作用对肥胖相关的人体测量和代谢危险因素产生影响。