BACKGROUND Inflammatory reaction is an essential factor in the occurrence, development and prognosis of femoropopliteal disease (FPD). The ratio of platelets to lymphocytes (PLR) is a new indicator reflecting platelet aggregation and burden of systemic inflammation. Our study is to explore the association between preoperative platelet-to-lymphocyte ratio (pre-PLR) and 6-month primary patency (PP) after drug-coated balloon (DCB) in FPD. METHODS There were 70 patients who underwent DCB for FPD contained in the study. According to 6-month PP, patients were divided into group A (PP ≥6 months, n = 54) and group B (PP < 6 months, n = 16). Logistic regression analysis was used to identify potential predictors for 6-month PP after DCB in FPD. A receiver operating characteristic (ROC) curve analysis was used to identify the cut-off value of pre-PLR to predict 6-month PP. RESULTS Logistic regression analysis showed that pre-PLR (OR: 1.008, 95% CI: 1.001-1.016, P = 0.031) and lesion length > 10 cm (OR: 4.305, 95% CI: 1.061-17.465, P = 0.041) were independently predictive for 6-month PP. The cutoff value of pre-PLR obtained from the ROC analysis was 127.35 to determine 6-month PP with the area of 0.839. Subgroup analysis was conducted based on the cutoff value of pre-PLR. The 6-month PP in the group of pre-PLR < 127.35 was higher than that of pre-PLR ≥ 127.35 group (p < 0.001). CONCLUSIONS The present study indicated that an elevated pre-PLR was an effective additional indicator for predicting early PP in FPD after DCB.

中文翻译：

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血小板与淋巴细胞的比率预测了股pop神经疾病的药物涂层球囊的6个月主要通畅。

背景技术炎症反应是股pop疾病（FPD）发生，发展和预后的重要因素。血小板与淋巴细胞的比率（PLR）是反映血小板聚集和全身性炎症负担的新指标。我们的研究旨在探讨FPD药物涂层球囊（DCB）术后术前血小板与淋巴细胞之比（pre-PLR）与6个月初次通畅（PP）之间的关系。方法本研究包含70例接受DCB进行FPD的患者。根据6个月的PP，将患者分为A组（PP≥6个月，n = 54）和B组（PP <6个月，n = 16）。使用Logistic回归分析来确定FPD中DCB后6个月PP的潜在预测因素。受试者工作特征（ROC）曲线分析用于确定PLR前的临界值，以预测6个月的PP。结果Logistic回归分析显示PLR前（OR：1.008，95％CI：1.001-1.016，P = 0.031）和病变长度> 10 cm（OR：4.305，95％CI：1.061-17.465，P = 0.041）独立预测6个月的PP。从ROC分析获得的pre-PLR的临界值为127.35，以确定6个月PP的面积为0.839。根据pre-PLR的临界值进行亚组分析。前PLR <127.35组的6个月PP高于前PLR≥127.35组（p <0.001）。结论本研究表明，PLR升高是预测DCB后FPD早期PP的有效附加指标。结果Logistic回归分析显示PLR前（OR：1.008，95％CI：1.001-1.016，P = 0.031）和病变长度> 10 cm（OR：4.305，95％CI：1.061-17.465，P = 0.041）独立预测6个月的PP。从ROC分析获得的pre-PLR的临界值为127.35，以确定6个月PP的面积为0.839。根据pre-PLR的临界值进行亚组分析。前PLR <127.35组的6个月PP高于前PLR≥127.35组（p <0.001）。结论本研究表明，PLR升高是预测DCB后FPD早期PP的有效附加指标。结果Logistic回归分析显示PLR前（OR：1.008，95％CI：1.001-1.016，P = 0.031）和病变长度> 10 cm（OR：4.305，95％CI：1.061-17.465，P = 0.041）独立预测6个月的PP。从ROC分析获得的pre-PLR的临界值为127.35，以确定6个月PP的面积为0.839。根据pre-PLR的临界值进行亚组分析。前PLR <127.35组的6个月PP高于前PLR≥127.35组（p <0.001）。结论本研究表明，PLR升高是预测DCB后FPD早期PP的有效附加指标。从ROC分析获得的pre-PLR的临界值为127.35，以确定6个月PP的面积为0.839。根据pre-PLR的临界值进行亚组分析。前PLR <127.35组的6个月PP高于前PLR≥127.35组（p <0.001）。结论本研究表明，PLR升高是预测DCB后FPD早期PP的有效附加指标。从ROC分析获得的pre-PLR的临界值为127.35，以确定6个月PP的面积为0.839。根据pre-PLR的临界值进行亚组分析。前PLR <127.35组的6个月PP高于前PLR≥127.35组（p <0.001）。结论本研究表明，PLR升高是预测DCB后FPD早期PP的有效附加指标。