BACKGROUND Previous studies have shown that patients with long-term diabetes require more opioids after surgery than patients without diabetes. Gestational diabetes mellitus (GDM) normally only lasts for a brief period; nevertheless, its effect on sufentanil consumption after cesarean section is unknown. METHODS This prospective cohort study included two groups: a GDM group (n = 32) and a matched non-GDM (NGDM) group (n = 32). All patients underwent routine combined spinal-epidural anesthesia for cesarean delivery. Sufentanil consumption through an intravenous patient-controlled analgesia (PCA) pump, the frequency of PCA requests, and visual analog scale (VAS) scores 6 and 24 h after surgery were compared between groups. RESULTS Sufentanil consumption (μg) 6 h after surgery was higher in the GDM group than in the NGDM group (24.0 ± 6.6 vs 20.1 ± 5.7, P = 0.023). PCA was used more frequently 6 and 24 h after surgery by the GDM group than by the NGDM group (1[0-2] vs 0[0-1], P = 0.001; 6 [1-5] vs 3 [1, 2, 6-8], P = 0.001, respectively). The VAS score during activity 24 h after surgery was higher in the GDM group than in the NGDM group (5 [2, 3] vs 5 [1, 2], respectively, P = 0.03). CONCLUSION Pregnant women with GDM require more opioids during the immediate postoperative period after cesarean section than those without GDM. CLINICAL TRIALS REGISTRATION No. ChiCTR1800016014, ChenYang, May 6th 2018.

中文翻译：

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剖宫产后妊娠糖尿病对舒芬太尼消耗的影响：一项前瞻性队列研究。

背景技术以前的研究表明，与没有糖尿病的患者相比，长期糖尿病患者术后需要更多的阿片类药物。妊娠期糖尿病（GDM）通常只持续很短一段时间；然而，其对剖宫产后舒芬太尼消耗的影响尚不清楚。方法这项前瞻性队列研究包括两组：GDM组（n = 32）和匹配的非GDM（NGDM）组（n = 32）。所有患者均接受常规联合硬膜外麻醉用于剖宫产。比较两组患者术后6h和24h通过静脉内自控镇痛（PCA）泵舒芬太尼的消耗量，PCA请求的频率以及视觉模拟量表（VAS）评分。结果GDM组术后6 h舒芬太尼的消耗量（μg）高于NGDM组（24.0±6.6 vs 20）。1±5.7，P = 0.023）。与NGDM组相比，GDM组在术后6和24小时使用PCA的频率更高（1 [0-2] vs 0 [0-1]，P = 0.001； 6 [1-5] vs 3 [1， 2，6-8]，P = 0.001）。GDM组术后24小时活动期间的VAS评分高于NGDM组（分别为5 [2，3]和5 [1,2,5]，P = 0.03）。结论剖宫产术后GDM孕妇在术后即刻需要的阿片类药物要多于GDM孕妇。临床试验注册号ChiCTR1800016014，陈阳，2018年5月6日。GDM组术后24小时活动期间的VAS评分高于NGDM组（分别为5 [2，3]和5 [1,2,5]，P = 0.03）。结论剖宫产术后GDM孕妇在术后即刻需要的阿片类药物要多于GDM孕妇。临床试验注册号ChiCTR1800016014，陈阳，2018年5月6日。GDM组术后24小时活动期间的VAS评分高于NGDM组（分别为5 [2，3]和5 [1,2,5]，P = 0.03）。结论剖宫产术后GDM孕妇在术后即刻需要的阿片类药物要多于GDM孕妇。临床试验注册号ChiCTR1800016014，陈阳，2018年5月6日。