Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease.,Molecular Nutrition & Food Research

当前位置： X-MOL 学术 › Mol. Nutr. Food Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-01-16 , DOI: 10.1002/mnfr.201900890
Roberta Ruotolo ₁ , Ilaria Minato ₁ , Pietro La Vitola ₂ , Luisa Artioli ₂ , Claudio Curti ₃ , Valentina Franceschi ₄ , Nicoletta Brindani ₃ , Davide Amidani ₁ , Laura Colombo ₅ , Mario Salmona ₅ , Gianluigi Forloni ₂ , Gaetano Donofrio ₄ , Claudia Balducci ₂ , Daniele Del Rio ₄ , Simone Ottonello _{1,

6}

Affiliation

Amyloid‐β oligomers (AβO) are causally related to Alzheimer's disease (AD). Dietary natural compounds, especially flavonoids and flavan‐3‐ols, hold great promise as potential AD‐preventive agents but their host and gut microbiota metabolism complicates identification of the most relevant bioactive species. This study aims to investigate the ability of a comprehensive set of phenyl‐γ‐valerolactones (PVL), the main circulating metabolites of flavan‐3‐ols and related dietary compounds in humans, to prevent AβO‐mediated toxicity.

中文翻译：

类黄酮衍生的人苯基-γ-戊内酯代谢物在阿尔茨海默氏病小鼠模型中选择性解毒淀粉样-β低聚物并防止记忆力减退。

淀粉样β-低聚物（AβO）与阿尔茨海默氏病（AD）因果相关。膳食天然化合物，尤其是类黄酮和黄烷3-ol，有望作为潜在的AD预防剂，但它们的宿主和肠道微生物群代谢使最相关生物活性物种的鉴定变得复杂。这项研究旨在研究全面的苯基-γ-戊内酯（PVL），黄烷-3-醇和相关饮食化合物在人体内的主要循环代谢产物预防AβO介导的毒性的能力。

更新日期：2020-01-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11