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Benefits of the ipowder® extraction process applied to Melissa officinalis L.: improvement of antioxidant activity and in vitro gastro-intestinal release profile of rosmarinic acid.
Food & Function ( IF 5.1 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9fo01144g Valérie Bardot 1 , Anaïs Escalon , Isabelle Ripoche , Sylvain Denis , Monique Alric , Sandrine Chalancon , Pierre Chalard , César Cotte , Lucile Berthomier , Martin Leremboure , Michel Dubourdeaux
Food & Function ( IF 5.1 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9fo01144g Valérie Bardot 1 , Anaïs Escalon , Isabelle Ripoche , Sylvain Denis , Monique Alric , Sandrine Chalancon , Pierre Chalard , César Cotte , Lucile Berthomier , Martin Leremboure , Michel Dubourdeaux
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The objective of this study was to evaluate the benefits of a new extraction process, the ipowder® technology, applied to Melissa officinalis L. Compared to M. officinalis ground dry leaves, the ipowder® had a similar phytochemical fingerprint but contained twice the concentration of rosmarinic acid (by HPTLC and HPLC) and had a two-fold greater antioxidant activity (DPPH* method). In vitro digestion experiments (TIM-1 model) showed better availability of rosmarinic acid for intestinal absorption with the ipowder® than with ground dry leaves, manifested by a three-fold reduction in the quantity of ingested product needed for delivery of the same amount of rosmarinic acid into the upper gastro-intestinal tract. This study shows that the ipowder® technology preserves all the original plant compounds intact while making some active ingredients more accessible and available to exert their effects. To obtain a given effect, the amount of ipowder® extract to ingest will therefore be lower; a reduction in the daily dosage will be more convenient for the patient and will improve patient compliance with supplementation.
中文翻译：
ipowder® 提取工艺应用于 Melissa officinalis L. 的优点：改善迷迭香酸的抗氧化活性和体外胃肠道释放特性。
本研究的目的是评估新提取工艺（即 ipowder® 技术）应用于香蜂草的益处。与香蜂草磨碎的干叶相比，ipowder® 具有相似的植物化学指纹，但含有两倍浓度的香蜂草。迷迭香酸（通过 HPTLC 和 HPLC）并具有两倍以上的抗氧化活性（DPPH* 方法）。体外消化实验（TIM-1 模型）表明，与磨碎的干叶相比，ipowder® 的迷迭香酸更容易被肠道吸收，表现为输送相同量的迷迭香酸所需的摄入量减少了三倍。迷迭香酸进入上胃肠道。这项研究表明，ipowder® 技术完整地保留了所有原始植物化合物，同时使一些活性成分更容易获得并发挥其作用。为了获得给定的效果，ipowder®提取物的摄入量会因此降低；每日剂量的减少对患者来说会更加方便，并且会提高患者对补充剂的依从性。
更新日期：2020-02-13
中文翻译：
ipowder® 提取工艺应用于 Melissa officinalis L. 的优点：改善迷迭香酸的抗氧化活性和体外胃肠道释放特性。
本研究的目的是评估新提取工艺（即 ipowder® 技术）应用于香蜂草的益处。与香蜂草磨碎的干叶相比，ipowder® 具有相似的植物化学指纹，但含有两倍浓度的香蜂草。迷迭香酸（通过 HPTLC 和 HPLC）并具有两倍以上的抗氧化活性（DPPH* 方法）。体外消化实验（TIM-1 模型）表明，与磨碎的干叶相比，ipowder® 的迷迭香酸更容易被肠道吸收，表现为输送相同量的迷迭香酸所需的摄入量减少了三倍。迷迭香酸进入上胃肠道。这项研究表明，ipowder® 技术完整地保留了所有原始植物化合物，同时使一些活性成分更容易获得并发挥其作用。为了获得给定的效果，ipowder®提取物的摄入量会因此降低；每日剂量的减少对患者来说会更加方便，并且会提高患者对补充剂的依从性。
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